Clusterin在乳腺癌中的表达及临床意义

目的:探讨凋亡抑制因子Clusterin在乳腺癌组织中的表达及临床意义。方法:应用免疫组织化学法检测60例乳腺癌、10例乳腺良性病变和10例乳腺正常组织中Clusterin的表达情况,并探讨Cluslerin表达与乳腺癌各临床病理学参数间的关系。结果:Clusterin在乳腺正常组织、乳腺良性病变及乳腺癌组织中的阳性表达率分别为0%、10%及78_33%,乳腺癌组织中的Clusterin表达水平明显高于乳腺良性病变及乳腺正常组织(均P<0.01);Clusterin在乳腺癌中的表达与组织学分级、淋巴结转移相关(P<0.05),与年龄、肿瘤直径及临床分期无关;在乳腺癌组织中Cluslerin与ER、PR的表达负相关,与C-erbB-2的表达无明显相关,与p53、Ki67的表达呈正相关。结论:Clusterin可能通过抑制细胞凋亡在乳腺癌的发生发展中发挥重要作用,并有可能成乳腺癌治疗的新靶点。

The expression of Clusterin protein in breast carcinoma and its clinical significance

Objective:To investigate the protein expression of Clusterin in breast cancer and its clinical significance.Methods: Clusterin expression were examined by immunohistochemical staining method in 60 cases with breast cancer,10 cases with benign pathological changes and 10 cases with normal breast tissues.Results:The positive rates of Clusterin in normal breast tissues,benign pathological changes and breast cancer tissues were 0%,10% and 78.33%,respectively.The expression of Clusterin in breast cancer was much higher than that in nor,hal breast tissues(P<0.05)and benign pathological cbanges(P<0.05).The expression of Clusterin in breast cancer tissues was closely related to histological type(P<0.05)and lymph node metastasis(P<0.05).but no correlated to the age,tumor size and clinical stage.There was a negative correlation between ER,PR and Clusterin.There was no correlation between C-erbB-2 and Clusterin.There was a positive correlation between p53,Ki67 and Clusterin.Conclusion:Clusterin may play an important role in the biological characteristics of breast cancer by the antiapoptosis pathway.It may be used as a potential therapeutic target for breast cancer.