双光气中毒对家兔肺血液动力学的影响

家兔双光气中毒后平均肺动脉压(MPAP)及肺血管阻力(PVR)明显增加,持续2～3h。肺循环逆流灌注液中微栓(21.8×10~6/L)和白细胞(798×10~6/L)与对照组(1×10~6/L和430×10~6/L)比较均有明显增加。肺湿干比(5.74)及肺水含量(81.6％)与对照组(4.8和79.0％)比较也均有明显增加。心阻抗参数(Z_0,SV,CO,CI)中毒前后无明显差异。山莨菪碱(anisodamine)能改善双光气中毒后的肺血液动力学指标,但不能有效地阻止肺水肿形成。

Effects of diphosgene poisoning on the pulmonary hemodynamics in rabbits

The purpose of this study was to examine the changes of pulmonary hemodynamics, cardiac impedance parameters and the number of pulmonary microembolus, and leukocyte after diphosgene inhalation in rabbits. Fifty-three rabbits were randomized into two sets, one set was used to monitor the pulmonary hemodynamics, the other set was used to determine the cardiac impedance parameters, microemboli and leukocytes were obtained directly from the pulmonary microcirculation by use of the retrograde perfusion method.As compared with control group, it was found that pulmonary artery pressure rose and pulmonary vascular resistance increased (p<0.05), but did notcorrelate with lung water parameters (p>05). At 1, 6 h after diphosgene inhalation cardiac impedance parameters did not change (p>0.05), as compared with before inhalation. Microemboli (21.8 x 106/L) and leukocytes (798x106/L) were significantly increased (p<0.05), as compared with the control group (1x106/L, 430x106/L, respectively). Anisodamine could improve the pulmonary hemodynamics, but could not effectively reduce the degree of pulmonary edema.