| 醒脑静中各味药物及全方对栀子提取物肠吸收的影响 |
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| 引用本文： | 杜守颖,张倩怡,陆洋,翟永松,吴清.醒脑静中各味药物及全方对栀子提取物肠吸收的影响[J].中国中药杂志,2010,35(3):297-300. |
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| 作者姓名： | 杜守颖 张倩怡 陆洋 翟永松 吴清 |
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| 作者单位： | 北京中医药大学,中药学院,北京,100102 |
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| 基金项目： | 科技部"重大新药创制"科技重大专项(2009ZX09502-008) |
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| 摘 要： | 目的:考察醒脑静处方中艾片、麝香、郁金及合方后对栀子提取物肠吸收的影响.方法:采用大鼠在体肠吸收模型研究方中不同配伍条件下栀子提取物有效成分栀子苷的肠吸收情况.结果:栀子提取物质量浓度为0.8 g·L~(-1)(含栀子苷0.311 g·L~(-1))时栀子苷吸收速率常数为(0.055±0.006)h~(-1)(以栀子苷计);栀子提取物分别与艾片、郁金、麝香配伍时吸收速率常数分别为(0.072±0.010),(0.060±0.001),(0.066±0.008)h~(-1),合方后吸收速率常数为(0.076±0.011)h~(-1).经统计学分析,单味栀子组与配伍艾片组的吸收速率常数间有显著性差异(P=0.03),与配伍郁金和配伍麝香组的吸收速率常数间无显著性差异,与复方组的吸收速率常数间有显著性差异(P=0.02).结论:配伍艾片及复方给药时可以显著促进栀子提取物中栀子苷的肠吸收.
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| 关 键 词： | 醒脑静 栀子提取物 肠吸收 艾片 麝香 郁金 |
| 收稿时间： | 2009/6/22 0:00:00 |
Study of components in Xingnaojing affecting intestine absorption of gardenia extract |
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| DU Shouying,ZHANG Qianyi,LU Yang,ZHAI Yongsong and WU Qing.Study of components in Xingnaojing affecting intestine absorption of gardenia extract[J].China Journal of Chinese Materia Medica,2010,35(3):297-300. |
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| Authors: | DU Shouying ZHANG Qianyi LU Yang ZHAI Yongsong and WU Qing |
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| Institution: | School of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China;School of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China;School of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China;School of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China;School of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China |
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| Abstract: | |
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| Keywords: | gardenia extract in situ intestinal perfusion model borneol moschus radix curcumae |
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