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Central Giant Cell Lesion |
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| Authors: | James C. Valentine Brenda L. Nelson |
| Affiliation: | (1) Department of Anatomic Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134-5000, USA |
| Abstract: | A classic case of central giant cell lesion (CGCL) is presented with emphasis on clinical, radiologic, and histologic features. The differential is discussed including peripheral giant cell granuloma, brown tumor of hyperparathyroidism, and giant cell tumor of bone. The molecular pathway of osteoclastogenesis is selectively reviewed and applied to suggest possible etiologies of the giant cell lesions. CGCL syndromes and treatment are also discussed. |
| Keywords: | Central giant cell lesion Giant cell reparative granuloma Osteoclast Giant cell RANK RANKL NFAT NFATc1 SH3BP2 Peripheral giant cell granuloma Giant cell tumor of bone Brown tumor of hyperparathyroidism Osteitis fibrosa cystica |
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