|
|||||
|
|
| 人参多糖对创伤脓毒症患者免疫功能和细胞因子的影响 | |
| 引用本文： | 瞿星光,张朝晖,周刚,龚勋,张蓉,曾超,李灵丰. 人参多糖对创伤脓毒症患者免疫功能和细胞因子的影响[J]. 现代中西医结合杂志, 2011, 20(23): 2866-2868 |
| 作者姓名： | 瞿星光 张朝晖 周刚 龚勋 张蓉 曾超 李灵丰 |
| 作者单位： | 三峡大学第一临床医学院宜昌市中心人民医院,湖北,宜昌,443003 |
| 摘 要： | 目的研究人参多糖对创伤脓毒症患者炎症因子及免疫功能的影响,探讨人参多糖在外科感染治疗中的作用。方法 48例创伤脓毒症患者随机分为治疗组24例和对照组24例,对照组采用经典SSC治疗,治疗组在上述治疗基础上加用人参多糖,疗程为7 d。分别观察治疗前和治疗后2组患者相关临床资料和生存分析,比较APACHEⅡ评分,血浆内毒素,肿瘤坏死因子(TNF-α),白细胞介素-6(IL-6),白细胞介素-10(IL-10),CD14+单核细胞HLA-DR,NK细胞和T细胞亚群CD4+、CD8+、CD4+/CD8+百分率的变化。结果治疗组患者机械通气和使用升压药的时间较对照组均明显缩短(P均<0.05);2组APACHEⅡ评分治疗前比较无显著性差异,治疗后第7天时治疗组明显低于对照组(P<0.05)。2组之间28 d病死率比较无显著性差异(P>0.05)。与对照组比较,治疗组内毒素、TNF-α、IL-6水平明显下降,IL-10水平明显升高,CD14+单核细胞HLA-DR,NK细胞和T细胞亚群CD4+、CD8+、CD4+/CD8+均明显上升(P均<0.05)。结论人参多糖可以减轻创伤脓毒症患者的炎症反应,改善其免疫功能,缩短机械通气和使用升压药的时间。 |
| 关 键 词： | 人参多糖 创伤 脓毒症 免疫疗法 |
Effect of ginseng polysaccharide on immune function and cytokines in patients with posttraumatic sepsis |
|
| Qu Xingguang,Zhang Zhaohui,Zhou Gang,Gong Xun,Zhang Rong,Zeng Chao,Li Lingfeng. Effect of ginseng polysaccharide on immune function and cytokines in patients with posttraumatic sepsis[J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2011, 20(23): 2866-2868 | |
| Authors: | Qu Xingguang Zhang Zhaohui Zhou Gang Gong Xun Zhang Rong Zeng Chao Li Lingfeng |
| Affiliation: | Qu Xingguang,Zhang Zhaohui,Zhou Gang,Gong Xun,Zhang Rong,Zeng Chao,Li Lingfeng(The First Clinical Medical College of Three Gorges University,The Central People's Hospital of Yichang City,Yichang 443003,Hubei,China) |
| Abstract: | Objective It is to study the influence of ginseng polysaccharide on inflammatory factors and immune function in the patients with posttraumatic sepsis and to approach the role of ginseng polysaccharide in the therapy for surgical infection.Methods Forty-eight patients with posttraumatic sepsis were divided into treatment group and control group in which there were both 24 cases.The control group received classical SSC therapy and the treatment group received classical SSC therapy plus ginseng polysaccharide... |
| Keywords: | ginseng polysaccharide trauma sepsis immunotherapy |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |