| 结核病患者外周血树突状细胞及其亚群的变化 |
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| 引用本文： | 黄家禹,宋秀宇,洪强,叶志忠. 结核病患者外周血树突状细胞及其亚群的变化[J]. 细胞与分子免疫学杂志, 2010, 26(4) |
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| 作者姓名： | 黄家禹 宋秀宇 洪强 叶志忠 |
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| 作者单位： | 1. 福建医科大学附属厦门第一医院检验科,福建厦门,361003
2. 福建医科大学附属厦门第一医院杏林分院肺科,福建厦门,361003 |
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| 摘 要： | 目的:分析不同结核病患者外周血树突状细胞(DCs)及其亚群的变化,并进行免疫机制探讨。方法:就诊于我院2008-11/2009-08的结核病患者32例(实验组),同期在我院进行健康体检者11例(对照组),采用流式细胞术(FCM)检测了结核病患者(包括19例初治患者和13例复治患者,以及痰涂片结果不同的19例肺结核患者)和对照组中外周血中DCs及其亚群的变化。结果:实验组DC1亚群的比率和DCs的总数分别为(0.28±0.13)%和(0.42±0.19)%,明显低于对照组的DC1亚群的比率和DCs的总数(0.47±0.23)%和(0.65±0.22)%(P0.01)。痰涂片阳性患者外周血中DC1亚群的比率和DCs的总数分别为(0.16±0.04)%和(0.24±0.06)%,明显低于痰涂片阴性患者DC1亚群的比率和DCs的总数(0.28±0.14)%和(0.43±0.12)%(P0.05)。初治患者与复治患者外周血中DCs的总数及其亚群的比率无统计学意义(P0.05)。结论:DCs可作为结核病传染源初筛和抗结核疗效观察的参考指标,反映不同结核病患者的免疫状态。
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| 关 键 词： | 结核病 外周血 树突状细胞 |
Changes of dendritic cells and its subsets in peripheral blood of patients with mycobacterium tuberculosis |
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| HUANG Jia-yu,SONG Xiu-yu,HONG Qiang,YE Zhi-zhong. Changes of dendritic cells and its subsets in peripheral blood of patients with mycobacterium tuberculosis[J]. Chinese journal of cellular and molecular immunology, 2010, 26(4) |
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| Authors: | HUANG Jia-yu SONG Xiu-yu HONG Qiang YE Zhi-zhong |
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| Affiliation: | HUANG Jia-yu1,SONG Xiu-yu1,HONG Qiang1,YE Zhi-zhong2Xiamen First Hospital Affiliated to Fujian Medical University:1Department of Clinical Laboratory,2Pulmonary Department of Xinglin Branch,Xiamen 361003,China |
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| Abstract: | AIM:To analyze the changes of dendritic cells and its subsets in peripheral blood of patients with mycobacterium tuberculosis,and to explore its immune mechanism. METHODS:32 patients with mycobacterium tuberculosis and 11 healthy controls were selected,who were diagnosed in our hospital from Nov. 2008 to Aug. 2009. The patients included 19 initial-treatment cases and 13 retreatment cases,and 19 lung tuberculosis patients with different sputum tests. Dendritic cells and its subsets in peripheral blood were d... |
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| Keywords: | Mycobacterium tuberculosis peripheral blood dendritic cells |
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