| 几种细胞增殖活性研究方法的评估 |
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| 引用本文： | 刘复兴,黄孝立.几种细胞增殖活性研究方法的评估[J].咸宁医学院学报,1997,11(2):64-67. |
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| 作者姓名： | 刘复兴 黄孝立 |
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| 作者单位： | 咸宁医学院病理学教研室(刘复兴)，河南医科大学病理学教研室(黄孝立) |
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| 摘 要： | 为确立一种更能准确反映细胞增殖活性的方法,分别用免疫组化LSAB法和胶银染色法,对50例食管癌进行了PCNA和C-myc表达的半定量分析和AgNORs计数。结果PCNA标记百分率在不同程度分化的食管癌中差异显著(P<0.05),而C-myc和AgNORs计数在各级之间结果重叠。PCNA标记百分率是一个更能准确反映细胞增殖活性的良好指标。在肿瘤诊断中具有较高实用价值。
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| 关 键 词： | 增殖活性 免疫组织化学 核仁组成区 食管鳞癌 |
Evaluation of Several Study Methods in Cellular Proliferative Activity |
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| Liu Fuxin et al.Evaluation of Several Study Methods in Cellular Proliferative Activity[J].Journal of Xianning Medical College,1997,11(2):64-67. |
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| Authors: | Liu Fuxin |
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| Institution: | Liu Fuxin et al Department of Pathology |
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| Abstract: | In order to establish a method to determine the cell proliferative activity more accurately, 50 cases of esophageal squamous cell carcinoma (ESCC) were analyzed by LSAB immunohisto-chemistry and argyrophilic nucleolar organizer regions (AgNORs) protein. There was significant difference of the expression of PCNA among the groups of ESCC with various degree of differentiation (P<0.05). The difference of the expression of c-myc oncoprotein or AgNORs-counting among them was not significant (P>0.05).As a result of the experiment PCNA is a better index in diagnosis of tumors, for it can reflect cellular proliferative activity more accurately. |
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| Keywords: | proliferative activity AgNORs immunohistochemistry tumor |
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