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FLT3 inhibitor KRN383 on xenografted human leukemic cells harboring FLT3-activating mutations FLT3 in AML: much more to learn about biology and optimal targeting |
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| Authors: | Giles Francis J |
| Affiliation: | aMD Anderson Cancer Center, Department of Leukemia, University of Texas, 1515 Holcombe Boulevard Box 428, Houston, TX 77030, USA |
| Abstract: | Aberrant FLT3 function in leukemia blasts is associated with a poor prognosis. A number of FLT3 modulators are in development. FLT3 mutations may synergistize with other molecular abnormalities in myeloid transformation. Further insights into FLT3 biology are needed to optimally study the therapeutic role of FLT3 inhibitors. |
| Keywords: | FLT3 Inhibitiors PKC412 KRN383 |
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