Survivin和Livin在喉鳞状细胞癌组织中的表达及意义

目的进一步探讨喉鳞状细胞癌（喉鳞癌）的发生机制。方法选择手术切除的喉鳞癌标本50份（观察组）、正常喉黏膜标本50份（对照组）,采用免疫组化法检测存活素（Survivin）和活素（Livin）表达情况,采用Spearman等级相关分析法分析两指标间及与喉鳞癌病理特征的关系。结果观察组与对照组Survivin阳性表达率分别为64%、0%,Livin阳性表达率分别为48%、4%,两两比较P均〈0.05;两者的表达与喉鳞癌TNM分期、淋巴结转移、组织分化程度密切相关;Survivin和Livin在喉鳞癌组织中的表达无明显相关性。结论Survivin和Livin的异常表达可促进喉鳞癌的发生、发展及转移;二者可用于喉鳞癌患者预后的判断。

Expression and significance of Survivin and Livin in laryngeal squamous cell carcinoma tissue

Objective To explore the pathogenesis of the laryngeal squamous cell carcinoma（LSCC）.Methods Immunohistochemical staining was used to detected the expression of Survivin and Livin in 50 LSCC specimens（observation group） and 50 normal laryngeal mucosa specimens（control group）,spearman rank correlation was used to analysis the relationship between the two indexes and pathological features of LSCC.Results The positive expression rate of Survivin in the observation group and control group were 64% and 0%,which of the Livin were 48% and 4%,both of which showed that P〈0.05;the expreesion of Survivin and Livin were closely correlated to the TNM stage,lymph node metastasis and histological grade of LSCC.The expression of Survivin and Livin in of LSCC showed no significant correlation.Conclusion The abnormal expression of Survivin and Livin can promote the development and transfer of the of LSCC;both of them can be used for the prognosis evaluation of LSCC.