The effects of chronic ritanserin treatment on sleep and the neuroendocrine response to l-tryptophan |
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| Authors: | C Idzikowski P J Cowen D Nutt F J Mills |
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| Institution: | (1) Clinical Pharmacology Unit, Janssen Pharmaceutical Ltd, OX12 0DQ Grove, Wantage, Oxon., UK;(2) MRC Clinical Pharmacology Unit and Research Unit, University Department of Psychiatry, Littlemore Hospital, OX4 4XN Oxford, UK;(3) National Institute of Alcohol Abuse in Alcoholism, 9000 Rockville Place, Bethesda, Maryland, USA |
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| Abstract: | A previous study has shown that acute administration of the 5-HT2 receptor antagonist ritanserin doubles Slow Wave Sleep (SWS) and increases the prolactin (PRL) response to l-tryptophan (LTP). The present study investigated the effect of repeated ritanserin treatment on sleep, neuroendocrine response to LTP and 5-HT2 platelet receptor binding. After 2 weeks, ritanserin administration SWS was persistently increased but the PRL response to LTP was unchanged. Platelet 5-HT receptor binding was undetectable at the end of ritanserin treatment but recovered 2 weeks after drug withdrawal. The results suggest that ritanserin causes a sustained effect on the 5-HT mechanisms mediating SWS and on platelet 5-HT2 receptors. However, adaptation occurs to its effect on 5-HT-mediated neuroendocrine responses. |
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| Keywords: | 5-HT2 antagonist Sleep Platelet Tryptophan Prolactin Growth hormone 5-HT-receptors |
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