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| 淫羊藿苷对快速老化小鼠SAMP8学习记忆功能影响的研究 | |
| 引用本文： | 唐千淇,高琳娜,毕明刚.淫羊藿苷对快速老化小鼠SAMP8学习记忆功能影响的研究[J].黑龙江医药,2012,25(3):359-362. |
| 作者姓名： | 唐千淇 高琳娜 毕明刚 |
| 作者单位： | 1. 哈尔滨商业大学生命科学与环境科学研究中心 黑龙江 哈尔滨 150076 2. 河北北方学院 张家口 075029 3. 北京中国医学科学院药用植物研究所 北京 100193;中国医学科学院药物研究所 北京 100050 |
| 摘 要： | 目的:研究淫羊藿苷(Icaritin,ICA)对快速老化小鼠SAMP8学习记忆功能的影响。方法:按体重随机挑选10只8月龄抗快速老化小鼠SAMR1和50只同月龄快速老化小鼠SAMP8,并将SAMP8随机分为5组(模型组、多奈哌齐组和ICA50mg/kg、100mg/kg、200mg/kg组),灌胃给药1个月,在给药前后分别用Morris水迷宫、SMG-2迷宫和跳台方法检测SAMR1和SAMP8的学习记忆功能能力。结果:与给药前相比,给药后的快速老化小鼠SAMP8定位航行和空间搜索能力以及被动反应能力得到提高。结论:ICA可以改善SAMP8的学习记忆能力。 |
| 关 键 词： | 淫羊藿苷 快速老化小鼠SAMP8 学习记忆功能 |
Study of Icariin Affect on Learning and Memory in Senescence Accelerated Mouse Prone/8 (SAMP8) |
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| Institution: | Tang Qianqi1,et al 1.Life and Environment Science Research Center,Harbin University of Commerce(Harbin 150076,China); |
| Abstract: | Objective:To study the effect of ICA on learning and memory for senescence accelerated mouse prone/8(SAMP8).Methods:10 eight-month-old SAMR1 and 50 the same age SAMP8 were selected. and SAMP8 were divided randomly into 5 groups(model,the donepezil,and ICA50mg/kg,100mg/kg,200mg/kg group),Then,the effects of icariin administration by oral gavage for one month on learning and memory in SAMP8 and SAMR1 have been investigated by the Morris water maze test,SMG-2water maze test and Step down test.Results:Compared with the former administration,after administration of the rapid aging mice SAMP8 place navigation and spatial search capability,as well as reactive capacity is improved.Conclusion:ICA could improve the learning and memory ability of SAMP8. |
| Keywords: | icariin senescence accelerated mouse Learning and memory |
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