迟发性运动障碍患者血清尿酸、催乳素水平相关性的研究

目的通过对迟发性运动障碍(TD)患者血清尿酸(UA)、催乳素(PRL)水平相关性的分析,探讨尿酸对TD保护作用的可能机制。方法测定伴TD的精神分裂症患者(TD组30例)血清尿酸、催乳素水平,并与不伴TD的精神分裂症患者(非TD组30例)进行对照;以异常不自主运动量表(AIMS)对TD临床症状进行评定。结果 TD组UA(273±36)μmmol/L]较非TD组(297±50)μmmol/L]显著降低(t=2.129,P=0.037);PRL(28±7)ng/ml]较非TD组(24±7)ng/ml]显著增高(t=-2.195,P=0.032)。TD组PRL水平与AIMS总分正相关(r=0.366,P=0.044);与血清UA水平负相关(r=-0.403,P=0.027)。结论 TD患者血清尿酸水平偏低、并与PRL水平负相关,尿酸对DA神经元可能有一定的保护作用。

Research on Correlation between the Serum Level of Uric Acid and Prolactin in Schizophrenia with Tardive Dyskinesia

Objective To explore the protective mechanism of uric acid in tardive dyskinesia（TD）via analyze the relationship between serum uric acid（UA）and prolactin（PRL）in schizophrenia with TD.Methods To assess the serum level of UA and PRL in schizophrenia with or without TD（both n=30）.Abnormal Involuntary Movement Scale（AIMS）was used to evaluate the severity of TD.Results The serum level of UA or PRL were significantly decreased or increased in patients with TD（273±36）μmmol/L,（28±7）ng/ml] than those in patients without TD（297±50）μmmol/L,（24±7）ng/ml;t=2.129,-2.195;P=0.037,0.032].The serum level of PRL had a significantly positive or negative relationship with total score of AIMS（r=0.366,P=0.044）or the serum level of UA（r=-0.403,P=0.027）.Conclusion The serum UA level is low in TD patients and negatively related to serum PRL,which suggest that UA may be involved in the protection of dopamine neurons.