| 补肾壮骨颗粒对兔膝骨性关节炎白介素-1和肿瘤坏死因子的影响 |
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| 引用本文： | 张爱玲,于沛林,王晓宁. 补肾壮骨颗粒对兔膝骨性关节炎白介素-1和肿瘤坏死因子的影响[J]. 光明中医, 2010, 25(3): 424-426. DOI: 10.3969/j.issn.1003-8914.2010.03.052 |
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| 作者姓名： | 张爱玲 于沛林 王晓宁 |
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| 作者单位： | 山东省青岛市海慈医疗集团,青岛,266033;山东省青岛市海慈医疗集团,青岛,266033;山东省青岛市海慈医疗集团,青岛,266033 |
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| 摘 要： | 目的观察补肾壮骨颗粒对兔膝骨性关节炎中白介素-1(IL-1)和肿瘤坏死因子(TNF)表达水平的影响,探讨其治疗骨性关节炎的机制。方法将50只兔随机分为4组,即补肾壮骨颗粒组20只、塞来昔布组20只、空白对照组5只、正常组5只,采用Hulth法造成骨关节炎的病理模型,以补肾壮骨颗粒浓缩液喂食饲养,于治疗后3、6周分别抽取关节液,采用双抗体夹心酶联免疫吸附法(ELISA),分别测定兔膝关节液中IL-1及TNF表达水平。结果治疗后3周,膝关节液中即可明显检测到IL-1及TNF的表达,各治疗组数值与对照组比较均见下降,3、6周时下降差异有统计学意义。结论补肾壮骨颗粒能降低骨性关节炎中IL-1及TNF的表达水平,补肾壮骨颗粒可能通过影响IL-1及TNF等细胞因子而对骨性关节炎起到治疗作用。
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| 关 键 词： | 骨性关节炎 补肾壮骨颗粒 白介素-1 肿瘤坏死因子 中医实验医学 中医骨伤科学 中医肿瘤实验医学 |
The Effect of Zhuanggu Capsule on IL-1 and TNF from Synovial Fluid in Rabbit with Qsteoarthritis |
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| Zhang Ailing,Yu Peilin,Wang Xiaoning. The Effect of Zhuanggu Capsule on IL-1 and TNF from Synovial Fluid in Rabbit with Qsteoarthritis[J]. Journal of Traditional Chinese Medicine, 2010, 25(3): 424-426. DOI: 10.3969/j.issn.1003-8914.2010.03.052 |
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| Authors: | Zhang Ailing Yu Peilin Wang Xiaoning |
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| Affiliation: | Zhang Ailing Yu Peilin Wang Xiaoning Sh,ong Pror ince Qingdao Medical Group,Qingdao 266033,China |
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| Abstract: | Objective:To observe the effect of zhuanggu capsule on the expressi on of IL-1 and TNF from synovial fluid in rabbit with osteoarthritis. M ethods:5 0 rabbits were randomly divided into 4 groups. 20 cases was in Zhuanggu group,20 cases was in Celecoxib group,5 cases was in normal group,5 cases was in black group. Osteoarthritis model was establis hed by Hulth Rabbits with osteoarthritis were interfered by zhuanggu capsule dec o ction. The expression of IL-1 and TNF from synovial fluid in rabbit with osteoa ... |
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| Keywords: | Osteoarthritis zhuanggu capsule Interleukin-1 Tumor necrosis factor TCM experimental medicine Traditional orthopedics and traumatology TCM oncology experimental medicine |
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