初诊原发性干燥综合征75例临床分析

目的：了解原发性干燥综合征（primary Sj gren′s syndrome,pSS）患者的临床特点,提高对本病的认识。方法：对75例pSS患者的临床与相关实验室资料进行回顾性分析。结果：主要首发临床表现是关节痛54例,口干51例,眼干44例,猖獗龋齿20例,发热19例,吞咽困难15例,腮腺肿大13例;实验室检测显示贫血27例,WBC减少26例,BPC减少11例。抗SSA或抗SSB阳性的患者眼干和中性粒细胞比例减低的发生率与SSA和SSB阴性者差异均有统计学意义（P〈0.05）。结论：pSS患者早期症状不典型,容易误诊、漏诊;诊断时应注意综合临床症状和实验室检查结果。

Clinical features of newly-diagnosed primary Sj(o)gren's syndrome:an analysis of 75 cases

Objective：To improve the diagnosis and treatment of primary Sjgren′s syndrome（pSS） by analyzing the clinical features of the disease.Methods：The clinical data and related laboratory tests of 75 pSS patients were reviewed.Results：The primarily incipient symptoms of pSS were arthralgia 54 cases,dry mouth 51 cases,dry eyes 44 cases,decayed tooth 20 cases,febrile 19 cases,dysphagic 15 cases and parotid enlargement 13 cases.Laboratory testes showed that 27 cases of the patients developed anemia,26 cases leucopenia and 11 cases thrombocytopenia.Patients with positive anti-SSA or anti-SSB antibodies had a higher incidence of dry mouth and neutropenia than those with negative auto-antibodies（P0.05）.Conclusions：The onset symptoms of pSS are diverse.It is easy to make misdiagnosis or missed diagnosis.Comprehensive clinical symptoms and laboratory tests should be included in making correct diagnosis of pSS.