二氧化碳激发试验评估脑血管储备功能的临床研究

目的:应用5％ CO2作为血管扩张介质,通过CT灌注成像(CTPI)及CT血管成像(CTA)分析基础状态和激发状态下正常受试者脑血流动力学及脑血管储备功能变化特点和临床意义.方法:对30名排除肺部和心脏疾病的正常受试者行基础态CTPI和CTA检查,吸入5％CO2和95％ O2混合气体2 min后行CTPI检查.结果:C...

Clinical study on carbon dioxide challenge for evaluation of cerebrovascular reserve

Objective：To investigate the clinical significance of differences between rest and challenge state of cerebrovascular hemodynamics and cerebrovascular reserves features of normal subjects by using CT perfusion Imaging（CTPI） and CT angiography（CTA）.Methods：30 normal subjects excluded heart and lung diseases underwent CTPI and CTA in rest state,and then performed CTPI after inhaling 5% CO2 containing 95% O2 for two minutes consecutively.Results：End expiration pressure of CO2,mean arterial pressure and mean pulse were（42.33±5.06）mmHg、（100.96±18.27）mmHg and（78.37±14.68）bpm.Between rest and challenge state,cerebral blood flow and cerebral blood volume showed obviously statistical differences（P0.05）,but time to peak showed no statistical differences.Conclusion：5% CO2 is good vasodilator in studying cerebral hemodynamics and cerebrovascular reserves of patients with cerebrovascular disease.