生长抑素及凝血酶联合奥美拉唑治疗急性上消化道出血的价值

目的探究急性上消化道出血患者应用生长抑素、凝血酶联合奥美拉唑治疗的效果。方法60例急性上消化道出血患者,随机分为对照组和观察组,各30例。对照组患者给予常规治疗+奥美拉唑治疗,观察组患者在对照组基础上给予生长抑素、凝血酶治疗。比较两组患者临床治疗效果;出血量、止血时间、住院时间;凝血功能指标[纤维蛋白原(Fib)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)]水平;不良反应发生情况。结果观察组患者的总有效率100.00%高于对照组的80.00%,差异具有统计学意义(P<0.05)。观察组患者的出血量(442.52±102.61)ml、止血时间(7.33±3.64)h、住院时间(10.32±2.51)d均优于对照组的(556.49±120.65)ml、(9.45±2.31)h、(12.95±3.35)d,差异均具有统计学意义(P<0.05)。观察组患者的Fib、APTT、PT水平分别为(393.64±49.58)mg/dl、(28.24±1.36)s、(10.52±1.92)s,均优于对照组的(320.14±48.61)mg/dl、(30.36±1.17)s、(12.66±2.04)s,差异均具有统计学意义(P<0.05)。观察组患者的不良反应发生率高于对照组,但差异无统计学意义(χ^2=1.176,P>0.05)。结论急性上消化道出血患者联合应用生长抑素、凝血酶以及奥美拉唑的效果显著,安全性好。

The value of somatostatin and thrombin combined with omeprazole in the treatment of acute upper gastrointestinal hemorrhage

Objective To investigate the effect of somatostatin and thrombin combined with omeprazole in the treatment of acute upper gastrointestinal hemorrhage.Methods A total of 60 patients with acute upper gastrointestinal hemorrhage were randomly divided into control group and observation group,with 30 cases in each group.The control group received conventional therapy+omeprazole,and the observation group received somatostatin and thrombin on the basis of the control group.The clinical therapeutic effect;amount of hemorrhage,hemostasis time and hospitalization time;coagulation indexes[fibrinogen(Fib),activited partial thomboplastin time(APTT),prothrombin time(PT)]level;occurrence of adverse reactions were compared between the two groups.Results The total effective rate 100.00%in the observation group was higher than 80.00%in the control group,and the difference was statistically significant(P<0.05).The amount of hemorrhage(442.52±102.61)ml,hemostasis time(7.33±3.64)h and hospitalization time(10.32±2.51)d in the observation group were better than(556.49120.65)ml,(9.45±2.31)h and(12.95±3.35)d in the control group,and their difference was statistically significant(P<0.05).The levels of Fib,APTT and PT were(393.64±49.58)mg/dl,(28.24±1.36)s and(10.52±1.92)s in the observation group,which were better than(320.14±48.61)mg/dl,(30.36±1.17)s and(12.66±2.04)s in the control group,and their difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was higher than that in the control group,but the difference was not statistically significant(χ^2=1.176,P>0.05).Conclusion The combined use of somatostatin,thrombin and omeprazole in patients with acute upper gastrointestinal hemorrhage is effective and safe.