超声引导微波消融对甲状腺良性结节患者甲状腺激素、应激反应和美容效果的影响

【目的】探讨超声引导微波消融对甲状腺良性结节患者甲状腺激素、应激反应和美容效果的影响。【方法】回顾性分析2017年1月至2018年1月本院收治的82例甲状腺良性结节患者的临床资料,根据手术方法的不同将其分为观察组(超声引导微波消融治疗,n=49)和对照组(常规手术治疗,n=33)。比较两组患者结节治疗成功率、甲状腺激素水平、炎症因子水平、美容效果及并发症情况。【结果】术后1年随访,对照组治疗成功率为95.7%(113/118)低于观察组的99.1%(114/115),差异无统计学意义(χ^2=2.633,P>0.05)。观察组美容效果满意率为95.92%(47/49)明显高于对照组的75.76%(25/33),差异有统计学意义(χ^2=4.361,P<0.05)。治疗后,两组游离三碘甲状腺原氨酸(FT3)和游离甲状腺素(FT4)水平低于治疗前,促甲状腺激素(TSH)水平高于治疗前,且两组比较差异均有统计学意义(P<0.05)。治疗后,观察组血清肿瘤坏死因子-α(TNF-α)水平高于治疗前,对照组血清C反应蛋白(CRP)、TNF-α、白细胞介素-6(IL-6)水平高于治疗前,且高于观察组,差异均有统计学意义(P<0.05)。治疗后,观察组并发症发生率为10.20%(5/49)显著低于对照组的30.30%(10/33),差异有统计学意义(χ^22=5.423,P<0.05)。【结论】超声引导微波消融治疗甲状腺良性结节的效果与常规手术相当,而且对甲状腺功能影响小,对机体应激反应小,美容效果好。

Effect of Ultrasound-guided Microwave Ablation on Thyroid Hormone,Stress Response and Cosmetic Effect in Patients with Benign Thyroid Nodules

【Objective】To investigate the effect of ultrasound-guided microwave ablation on thy-roid horm one,stress response and cosmetic effect in patients with benign thyroid nodules.【Methods】The clinical data of 82 patients with benign thyroid nodules treated in our hospital from January 2017 to January 2018 were retrospectively analyzed.33 patients receiving routine surgical treatm ent were divided into control group and 49 patients receiving ultrasound-guided microwave ablation were divided into observation group.The success rate of nodule treatm ent,nodule shrinkage,thyroid horm one level,inflam m atory factor level,cosmetic effect and complications were compared between the two groups.【Results】One year follow-up showed that the treatm ent success rate of the control group was 95.7%(113/118)lower than that of the observation group 99.1%(114/115),the difference was not statistically significant(χ^2=2.633,P>0.05).The cosmetic satisfaction rate of the observation group was 95.92%(47/49)which was significantly higher than that of the control group 75.76%(25/33).The difference was statistically significant(χ^2=4.361,P<0.05).After treatment,the levels of free triiodothyronine(FT3)and free thyroxine(FT4)in the two groups were lower than those before treatment,and the levels of thyrotropin(TSH)were higher than those before treatm en t,and the differences between the two groups were statistically significant(P<0.05).After treatment,the level of serum TNF-α in the observation group was higher than that before treatm en t,the level of serum C-reactive protein(CRP),TNF-α and interleukin-6(IL-6)in the control group was higher than that before treatment,and the difference was statistically significant(P〈0.05).After treatment,the incidence of complications in the observation group was 10.20%(5/49),which was significantly lower than that in the control group 30.30%(10/33),the difference was statistically significant(χ^2=5.423,P<0.05).【Conclusion】The effect of ultrasound-guided microwave ablation on benign thyroid nodule is similar to that of conventional operation,and it has little effect on thyroid function,little stress response to body and good cosmetic effect.