中西医结合治疗特应性皮炎的临床观察

目的 观察中西医结合治疗特异性皮炎的临床疗效及其作用机制。方法 将47例特异性皮炎患者随机分为中西医结合组和西药组。西药组单纯口服氯雷他定10 mg，每天1次。中西医结合组在西药组治疗基础上合并加味当归饮加减治疗，疗程4周。并用双抗体夹心ELISA法检测两组患者治疗前后外周血白细胞介素4、10、12（IL 4、IL 10、IL 12）水平。结果中西医结合组愈显率56%（14/25例），西药组为22.7%（5/22例），两组比较，差异有统计学意义（χ²=5.38，P<0.05）。治疗前两组患者与健康对照组比较，IL- 4、10水平升高，IL-12水平降低（均P<0.01）；治疗后中西医结合组3种细胞因子水平恢复正常，西药组无明显变化。两组比较， 差异有统计学意义（P<0.01）。结论 中西医结合治疗特应性皮炎疗效肯定，其作用机制可能与调节相关细胞因子水平有关。

Clinical Study on Treatment of Atopic Dermatitis by Integrated Traditional Chinese and Western Medicine

OBJECTIVE: To observe the clinical effects and explore the mechanism of the integrated traditional Chinese and Western medicine in treating atopic dermatitis (AD). METHODS: Forty-seven patients with AD were randomly assigned to two groups, the control group and the treated group, they were treated with conventional Western medicine (10 mg Loratadine tablet, once daily) and with integrated medicine additionally given modified Jiawei Danggui Decection besides Western medicine respectively for 4 weeks. Double-sandwich ELISA was used to detect the levels of interleukin- 4, -10 and -12 (IL-4, IL-10 and IL-12) before and after treatment. RESULTS: The total effective rate in the treated group was 56% (14/25 cases), better than that in the control group (22.7%, 5/22 cases), showing significant difference between the two groups (X2 = 5.38, P < 0.05). Before treatment the serum levels of IL-4, IL-10 were significantly higher and level of IL-12 was lower in AD patients as compared with those in healthy persons (P < 0.01); they all restored to normal in the treated group after treatment but unchanged in the control group, showing significant difference between the two groups (P < 0.01). CONCLUSION: The clinical effect of integrated traditional Chinese and Western medicine is ascertainable, its mechanism might be associated with the regulation on related cytokines.