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A Novel SPAST Mutation Results in Spastin Accumulation and Defects in Microtubule Dynamics
Authors:Rui Chen BSc  Shiyue Du BEng  Yanyi Yao PhD  Lu Zhang MSc  Junyu Luo BSc  Yinhua Shen MSc  Zhenping Xu PhD  Xiaomei Zeng PhD  Luoying Zhang PhD  Mugen Liu PhD  Chuang Yin MM  Beisha Tang PhD  Jun Tan PhD  Xuan Xu PhD  Jing Yu Liu PhD
Affiliation:1. College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, China;2. Medical Genetics Center, Maternal and Child Health Hospital of Hubei Province, Wuhan, China;3. College of Life Science and Technology, Xinxiang Medical University, Xinxiang, China;4. Department of Neurology, Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, China;5. Department of Neurology, Xiangya Hospital, Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, China;6. Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China
Abstract:
Keywords:hereditary spastic paraplegias  SPAST  spastin  microtubule-severing activity  microtubule dynamics
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