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Single-Trajectory Multiple-Target Deep Brain Stimulation for Parkinsonian Mobility and Cognition
Authors:Sanskriti Sasikumar MD  Melanie Cohn PhD  Irene E. Harmsen BSc  Aaron Loh MB  BCh   BAO  Sang Soo Cho PhD  Michel Sáenz-Farret MD  MSc  Ricardo Maciel MD  MSc  Derrick Soh MD  Alexandre Boutet MD  PhD  Jürgen Germann PhD  Gavin Elias BA  Ariana Youm MA  Katherine Duncan PhD  Nathan C. Rowland MD  PhD  Antonio P. Strafella MD  PhD  Suneil K. Kalia MD  PhD  Andres M. Lozano MD  PhD  Alfonso Fasano MD  PhD
Affiliation:1. Division of Neurology, University of Toronto, Toronto, Ontario, Canada;2. Department of Psychology, University of Toronto, Toronto, Ontario, Canada;3. Mitchell Goldhar MEG Unit, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada

Toronto Western Hospital, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada;4. Toronto Western Hospital, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada;5. Division of Brain, Imaging and Behaviour—Systems Neuroscience, Krembil Brain Institute, UHN, University of Toronto, Toronto, Ontario, Canada

Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea;6. Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, UHN, Toronto, Ontario, Canada;7. Movement Disorders Unit, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil;8. Department of Neurology, Alfred Hospital, Melbourne, Victoria, Australia;9. Toronto Western Hospital, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada

Joint Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada;10. Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina, USA;11. Division of Neurology, University of Toronto, Toronto, Ontario, Canada

Division of Brain, Imaging and Behaviour—Systems Neuroscience, Krembil Brain Institute, UHN, University of Toronto, Toronto, Ontario, Canada

Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, UHN, Toronto, Ontario, Canada

Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, CAMH, University of Toronto, Toronto, Ontario, Canada;12. Krembil Brain Institute, Toronto, Ontario, Canada

Toronto Western Hospital, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada

Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, Ontario, Canada

Abstract:
Keywords:cognitive impairment  controlled trial  deep brain stimulation  globus pallidus pars interna  nucleus basalis of Meynert  Parkinson's disease
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