| 纳米明胶粒子的制备及其表面改性 |
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| 引用本文： | 丁素丽,朱以华,杨晓玲.纳米明胶粒子的制备及其表面改性[J].医学教育探索,2004(5):523-526. |
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| 作者姓名： | 丁素丽 朱以华 杨晓玲 |
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| 作者单位： | 华东理工大学超细材料制备与应用教育部重点实验室，华东理工大学超细材料制备与应用教育部重点实验室，华东理工大学超细材料制备与应用教育部重点实验室 上海200237，上海200237，上海200237 |
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| 基金项目： | 国家自然科学基金(20276019)，国家863计划(2002AA302208)，上海市纳米专项(0243nm069)资助项目 |
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| 摘 要： | 用改进的二次单凝聚法制备了粒径在100nm左右的纳米明胶粒子，并考察了凝聚剂用量，pH值，胶凝时间和固化时间等因素的影响。得到最佳的工艺条件为：凝聚剂的体积分数为0．444，pH值为3．8，胶凝时间为10min，固化时间为25min。通过吸附聚对苯乙烯磺酸钠(PSS)，对明胶粒子进行表面改性，使其表面带有负电荷，用反滴定的方法测得最大吸附量为每克明胶粒子吸附8．23mg PSS，为后期在表面吸附带有正电荷的药物打下了基础。
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| 关 键 词： | 纳米明胶粒子 单凝聚 聚电解质 吸附 |
Preparation of Gelatin Nanoparticles by Desolvation and Surface Modification |
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| DING Su-li,ZHU Yi-hua,YANG Xiao-lingghai,China.Preparation of Gelatin Nanoparticles by Desolvation and Surface Modification[J].Researches in Medical Education,2004(5):523-526. |
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| Authors: | DING Su-li ZHU Yi-hua YANG Xiao-lingghai China |
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| Institution: | DING Su-li,ZHU Yi-hua~,YANG Xiao-lingghai,China |
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| Abstract: | Gelatin nanopaticles about 100 nm in diameter were prepared by two-step single-desolvation improved, and the influence of the content of flocculant, pH value, desolvating and hardening times was investigated, respectively. The optimum conditions for the preparation are as follows: volume fraction of flocculant, 0.444; pH value, 3.8; desolvating time, 10 min; and hardening time, 25 min. The surface of gelatin particles is modified by adsorbing sodium poly(styrene sulfonate)(PSS), which made it negatively charged, and the amount of adsorbed PSS per gelatin nanoparticle determined by titrating in reverse is 8.23 mg. It may be provide the base of adsorbing medicines with positive charge. |
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| Keywords: | gelatin nanoparticle single-desolvation polyelectrolate adsorption |
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