| 重组人白细胞介素-11对小鼠尾部表皮颗粒层形成和血清白细胞介素-2水平的影响 |
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| 引用本文： | 王进,李应全,谢青,王菊英,张岫美. 重组人白细胞介素-11对小鼠尾部表皮颗粒层形成和血清白细胞介素-2水平的影响[J]. 中国生化药物杂志, 2005, 26(3): 155-157 |
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| 作者姓名： | 王进 李应全 谢青 王菊英 张岫美 |
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| 作者单位： | 山东大学,医学院,药理学研究所,山东,济南,250012 |
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| 摘 要： | 目的观察重组人白细胞介素-11(rhIL-11)对小鼠尾部表皮颗粒层生成和血清白细胞介素-2(IL-2)水平的影响。方法采用小鼠尾部鳞片表皮颗粒层形成模型,不同组别的小鼠给予rhIL-11或甲氨喋呤,观察其对鼠尾鳞片表皮颗粒层和血清IL-2含量的影响。结果rhIL-11可显著促进小鼠尾部鳞片表皮颗粒层形成(P<0.01),并显著抑制血清IL-2的水平(P<0.01)。结论rhIL-11可抑制角质细胞增殖分化不全和减少促发因子IL-2的生成,对银屑病具有较好的防治作用。
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| 关 键 词： | 重组人白细胞介素-11 表皮颗粒层 银屑病 白细胞介素-2 |
| 文章编号： | 1005-1678(2005)03-0155-03 |
| 修稿时间： | 2004-08-30 |
Effects of recombinant human IL-11 on the formation of mouse-tail scale epidermis granular layer and the level of IL-2 in serum |
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| WANG Jin,LI Ying-quan,XIE Qing,WANG Ju-ying,ZHANG Xiu-mei. Effects of recombinant human IL-11 on the formation of mouse-tail scale epidermis granular layer and the level of IL-2 in serum[J]. Chinese Journal of Biochemical Pharmaceutics, 2005, 26(3): 155-157 |
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| Authors: | WANG Jin LI Ying-quan XIE Qing WANG Ju-ying ZHANG Xiu-mei |
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| Affiliation: | WANG Jin,LI Ying-quan,XIE Qing,WANG Ju-ying,ZHANG Xiu-mei Department of Pharmacology,School of Medicine,Shandong University,Jinan 250012,China |
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| Abstract: | Purpose To study the therapeutic effects of recombinant human interleukin-11 (rhIL-11) on the formation of mouse-tail epidermis granular layer and the level of IL-2 in serum.Methods The formation of mouse-tail scale epidermis was used as the epidermis parakeratosis model, and different groups of mouse were treated with rhIL-11 or methotrexate. Its action in regulating the formation of mouse-tail epidermis granular layer and the level of IL-2 was observed.Results The rhIL-11 significantly promoted the formation of mouse-tail epidermis granular layer and decreased the level of IL-2 in serum. Conclusion The rhIL-11 has good efficacy in treating animal psoriasis model by inhibiting keratinocyte proliferation and parakeratosis and by decreasing the level of IL-2. |
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| Keywords: | recombinant human interleukin-11 mouse-tail epidermis granular layer psoriasis interleukin-2 |
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