血管狭窄下游流场边壁压力分布的模型实验和数值模拟

针对低切应力不能完全解释狭窄下游流场内病变和病变严重程度分布的规律，本研究在已经建立的狭窄体外流体力学特性实验研究模型上，对流体力学的另一重要因素——压力进行检测，结合数值模拟的方法对其分布及分布变化规律进行深入研究。结果显示：模型实验检测和数值模拟计算结果一致性良好；狭窄下游流场出现显著的压力下降。低压力的分布区域与心血管狭窄病变的分布区域及其严重程度之间有高度的相似。研究提示：数值模拟计算可应用于微观流场的流体力学特性研究；狭窄下游流场低压力的分布和变化可能是低切应力之外导致局部血管边壁损伤的又一重要流体力学因素。

Model Experiment and Numerical Simulation of Marginal Pressure in the Flow Field downstream of the Stenostic Vessel in Vitro

For the defects of interpreting the relationship between the distribution and severity of vascular stenostic disease and the low shear stress, the study focus on and explore the rules of the pressure distribution and variation downstream of the stenostic vessel with the numerical simulation and the hydrodynamic model of turbulent flow separation area for in vitro experiment. The results reveal that there is a good compatibility between the model experiment and the numerical simulation; there exists a marked pressure decrease downstream of the stenosis. And the distribution area of low pressure is similar to the characteristic distribution of the stenostic vessel diseases. The study suggested that the numerical simulation can be applied in the study of micro-flow field; the presure distribution and variatioin downstream of the stenostic vessel maybe another factor to trigger the pathogenesis of vessel stenostic diseases.