Further evidence that CENP-C is a necessary component of active centromeres: studies of a dic(X; 15) with simultaneous immunofluorescence and FISH期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Further evidence that CENP-C is a necessary component of active centromeres: studies of a dic(X; 15) with simultaneous immunofluorescence and FISH

Authors:	Page, Scott L. Earnshaw, William C. Choo, K.H.Andy Shaffer, Lisa G.

Affiliation:	Department of Molecular and Human Genetics, Baylor College of Medicine Houston, TX 77030 ¹Department of Cell Biology and Anatomy, Johns Hopkins University School of Medicine Baltimore, MD 21205, USA ²Murdoch Institute for Research into Birth Defects, Royal Children's Hospital Parkville, Victoria 3052, Australia

Abstract:	The stability of certain dicentric chromosomes in humans seemsto result from inactivation of one centromere, yielding a functionallymonocentric chromosome. Centromere protein C (CENP-C) was previouslyshown to be present at active centromeres but absent from theinactive centromere of one homologous dicentric rearrangement.We have combined indirect immunofluorescence detection of CENP-Cand fluorescence in situ hybridization with chromo-some-specific

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