| 抗T淋巴细胞单克隆抗体治疗再生障碍性贫血的临床研究 |
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| 引用本文： | 王鲁群,张明珙.抗T淋巴细胞单克隆抗体治疗再生障碍性贫血的临床研究[J].解放军医学杂志,1996,21(3):171-173. |
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| 作者姓名： | 王鲁群 张明珙 |
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| 作者单位： | 济南军区总医院，山东医科大学附属医院 |
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| 摘 要： | 用抗人Ｔ巴细胞单克隆抗体ＳＭＵ３（抗ＣＤ３）ＳＭＵ８（抗ＣＤ８）治疗３２例再生障碍性贫血，基本治愈６例，缓解７例，明显进步１１例，无效８例，有效率７５％（２４／３２）。治疗前Ｔ淋巴细胞亚群ＣＤ４／ＣＤ８比例倒置，淋巴细胞表面ＨＬＡ－ＤＲ抗原表达增高，治疗后ＣＤ４／ＣＤ８比例恢复正常，ＨＬＡ－ＤＲ表达降低，无血清病及血细胞减少等严重毒副作用。
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| 关 键 词： | 再生障碍性贫血 抗淋巴细胞 单克隆抗体 治疗 |
CLINICAL STUDY ON THE TREATMENT OF APLASTIC ANEMIA WITH MONOCLONAL ANTI HUMAN T LYMPHOCYTE ANTIBODY |
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| Wang Luqun,Chi Cuifang,Kong Fansheng et al.CLINICAL STUDY ON THE TREATMENT OF APLASTIC ANEMIA WITH MONOCLONAL ANTI HUMAN T LYMPHOCYTE ANTIBODY[J].Medical Journal of Chinese People's Liberation Army,1996,21(3):171-173. |
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| Authors: | Wang Luqun Chi Cuifang Kong Fansheng |
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| Institution: | Wang Luqun,Chi Cuifang,Kong Fansheng et al. General Hospital of Jinan Command,Jinan 250031 |
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| Abstract: | The monoclonal anti human T lymphocyte antibodies SMU3 (anti CD3) and SMU8 (anti CD8) were used to treat 32 patients with aplastic anemia. The results showed that 6 patients were cured, remission and good response were achieved in 7 and 11 respectively. The other 8 patients had no response. The effective rate was 75% (24/32). The T cell subsets CD4/CD8 ratio was inverse and expression HLA DR antigen on the lymphocytes surface was higher before SMU3 and SMU8 therapy, and they returned to normal after therapy. No severe toxic and side effect such as serum disease or hematocytopenia was found. |
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| Keywords: | monoclonal antibody T lymphocyte anemia aplastic therapy |
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