宫颈癌人乳头状瘤病毒各基因型感染的研究

目的 探讨宫颈癌变人乳头状瘤病毒各种基因分型感染情况,为诊治宫颈癌提供参考.方法 对432例宫颈癌变患者脱落细胞标本进行HPV检测并分型.结果 宫颈病变患者HPV感染前5位的基因型为HPV16、HPV58、HPV18、HPV33、HPV31,检出率分别为41.44％、14.58％、12.50％、10.19％、7.64％；非鳞癌组患者HPV18感染率显著高于鳞癌组,差异有统计学意义(P＜0.05).结论 宫颈癌HPV基因分型有助于确定宫颈癌发生的高危因素及筛查高危人群,对宫颈癌的诊断和早期治疗有重要意义.

Analysis of different genotypes of human papillomavirus infection in cervical cancer

OBJECTIVE To explore the infection situation,of different genotypes of human papillomavirus(HPV) in cervical cancer,and provide the references for clinical work.METHODS Specimens of exfoliated cells from 432 cervical cancer patients were analyzed.RESULTS The infection rate of different genotypes of HPV from high to low was HPV16(41.44%),HPV58(14.58%),HPV18(12.50%),HPV33(10.19%) and HPV31(7.64%).The infection rate of HPV18 in non-squamous cell cancer was higher than that in squamous cell cancer(P<0.05).CONCLUSION HPV genotyping can help to determine the high risk factors and groups of cervical cancer patients,which will benefit to early diagnosis and therapy.