鲍氏不动杆菌致COPD患者继发医院获得性肺炎的耐药性分析

目的 了解医院慢性阻塞性肺疾病(COPD)患者肺部感染鲍氏不动杆菌(ABA)的耐药性,为临床医师合理用药提供试验依据.方法 鲍氏不动杆菌培养鉴定严格按照《全国临床检验操作规程》进行;药物敏感试验采用K-B法,结果判断按照CLSI折点评价;采用WHONET最新版本分析试验数据.结果 162株ABA对β-内酰胺类/β-内酰胺酶抑制剂复合制剂敏感率为66.0％～68.5％,对其他常用抗菌药物包括碳青霉烯类抗菌药物已产生了严重的耐药性;ABA泛耐药株检出率为23.5％.结论 临床医护人员应加强监控力度,遏制鲍氏不动杆菌医院感染的暴发流行.

Antibiotic resistance of Acinetobacter baumanniicausing hospital acquired pneumonia in patients with COPD

OBJECTIVE To understand the antibiotic resistance of Acinetobacter baumannii(ABA) causing hospital-acquired pneumonia in patients with chronic obstructive pulmonary diseases(COPD) and provide the experimental evidence for rational use of antibiotics.METHODS Referring to national guide to clinical laboratory procedures,ABA were cultured and identified.The antibiotic susceptibility testing was performed by K-B methods.The susceptibility testing results were assessed according to CLSI breakpoints and analyzed statistically by new version WHONET software.RESULTS The susceptibility rates of bata-lactam antibiotic in combination with bata-lactamase inhibitors(cefoperazone/sulbactam,piperacillin/tazobactam) against 162 strains of ABA were high,varying from 66.0% to 68.5%.Serious antibiotic resistance occurred in other commonly used antibiotics including carbopenems.The detection rate of pan-resistant strains was 23.5%.CONCLUSION Clinical staffs should strengthen the monitoring and controlling to restrain outbreak and prevalence of ABA causing nosocomial infections.