山萘酚-3-O-芸香糖苷磷脂复合物的制备与理化性质研究

目的：山萘酚-3-O-芸香糖苷磷脂复合物的制备和理化性质考察。方法：制备山萘酚-3-O-芸香糖苷的磷脂复合物，测定其与山萘酚-3-O-芸香糖苷的溶解度，并对两者的水油分配系数进行分析。结果：与山萘酚-3-O-芸香糖苷相比，磷脂复合物不仅在正辛醇中溶解性有明显改善，在水中溶解度也有所升高；在不同pH的水一正辛醇系统中，复合物的表观油一水分配系数与山萘酚-3-O-芸香糖苷相比有一定的差异。结论：山萘酚-3-O-芸香糖苷磷脂复合物可明显改善山萘-3-O-芸香糖苷在水正辛醇中的溶解性能。

Preparation and physicochemical properties of kaempferol-3-O-rutinoside phospholipids complex

Objective:To prepare kaempferol-3-O-rutinoside phospholipid complex and study its physic chemical properties.Methods:Solubility and water oil distribution coefficient of the complex were studied,and compared with kaempferol-3-O-rutinoside.Results:There were a great improvements in the solubility of kaempferol-3-O-rutinoside phospholipid complex both in water and in n-octanol.Some differences of apparent oil/water distribution coefficients in the systems consisted of different pH water and n-octanol were found between the complex and kaempferol-3-O-rutinoside.Conclusion:The drug-phospholipid complexes may show some superior chemico-physical properties and enhance the absorption of the drugs.