门静脉动脉化及部分肝切除术对肝硬化的影响

目的研究行部分肝切除术后PVA对肝硬化的影响，证实PVA能促进部分肝切除术后肝细胞再生，改善肝硬化。方法肝硬化模型犬随机分三组，A组肝脏42％切除＋门静脉动脉化；B组肝脏42％切除；C组对照组。实验中按计划行多普勒超声检查，血化验研究肝功能变化，检测血管内皮细胞标记抗原CD。结果A组肝重显著高于B组（P〈0．01）；A组肝功能的改善亦加快；血流动力学改变在术后A组高于其余二组；免疫组化检测血管内皮细胞标记抗原CD34计数A组高于其余二组。结论①门静脉动脉化有助于部分肝切除术后肝功能的改善；②门静脉动脉化增加肝细胞再生及改善肝硬化。

The effects of portal vein arterialization and party hepatectomy to the hepatocirrhosis

Objective To investigate the effects of portal vein arterializations(PVA) on hepatocirrhosis after party hepatectomy, proved that the PVA can increase the regeneration after party hepatectomy, and improve the hepatocirrhosis. Methods The cirrhosis model dogs were allocated randomly into three groups, dogs in group A received PVA after 42％ liver resection, in group B underwent 42％ liver resection only, group C was control group. During the experiment, Before operation, we used the color Doppler senograph to measure the hemodynamic change, the blood was taken to study the alteration of liver function and we use the immunohistochemical technique to exam CD34 of specimens. Results In group A liver weight is significant higher than group B(P＜0.01).The improvement of liver function was also faster in group A. The blood flew of group A was higher than other two groups in 2 ds(P＜0.05). In group A the vascular area defined by endothelial cells that stained for CD34 was higher than two groups. Conclusion ①The portal vein arterializations improve the cirrhosis liver function after partyhepatectomy. ②The portal vein erializations increase the liver regeneration and improve the epatocirrhosis.