Interleukin-2 receptor beta chain locus rearrangement in a T-cell acute lymphoblastic leukemia |
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| Authors: | Berger R Bernard O A |
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| Affiliation: | 1. EMI 0210 Inserm, Tour Pasteur, hôpital Necker–Enfants-Malades, 149, rue de Sèvres, 75743 Paris cedex 15, France;2. IRNEM, Paris-V, Paris, France |
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| Abstract: | A translocation t(1;22)(p13;q13) was detected in a child with T-cell acute lymphoblastic leukemia (T-ALL). FISH studies showed that the breakpoint was located in the 5' part of the interleukin-2 receptor beta chain (IL2RB) locus, but could only be located distal to 1p13.3 on the partner chromosome. This is the first case of the IL2RB locus rearrangement in T-ALL. The localization of the breakpoint suggests that the chromosomal translocation results in deregulation of IL2RB expression. |
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| Keywords: | IL2RB T-ALL Translocation |
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