| CXCR4与MMP-2在人直肠癌组织中的表达及临床意义 |
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| 引用本文： | 符炜,李爱娜,徐红,王玉兰.CXCR4与MMP-2在人直肠癌组织中的表达及临床意义[J].山东医药,2010,50(48):17-18. |
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| 作者姓名： | 符炜 李爱娜 徐红 王玉兰 |
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| 作者单位： | 1. 徐州医学院附属医院,江苏徐州,221009
2. 徐州医学院 |
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| 摘 要： | 目的探讨人直肠癌中CXCR4和MMP-2蛋白的表达及意义。方法采用免疫组织化学方法检测50例人直肠正常黏膜组织、癌组织和相关淋巴结中CXCR4和MMP-2的蛋白表达,并分析其与直肠癌临床病理特征的关系。结果 CXCR4和MMP-2在直肠癌组织中阳性率均明显高于正常黏膜组织;CXCR4和MMP-2的表达强度与肿瘤分期、分化程度和淋巴结转移有关,且两者存在正相关性。结论 CXCR4和MMP-2在直肠癌的表达呈正相关,并与直肠癌肿瘤的侵润、转移有关。
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| 关 键 词： | 结直肠肿瘤 CXCR4 基质金属蛋白酶2 |
Expression and significance of CXCR4 and MMP-2 in human rectal tumors |
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| FU Wei,LI Ai-na,XU Hong,WANG Yu-lan.Expression and significance of CXCR4 and MMP-2 in human rectal tumors[J].Shandong Medical Journal,2010,50(48):17-18. |
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| Authors: | FU Wei LI Ai-na XU Hong WANG Yu-lan |
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| Institution: | 1 Affiliated Hospital of Xuzhou Medical College,Xuzhou 221009,P.R.China) |
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| Abstract: | Objective To investigate the expression of CXCR4 and matrix metalloproteinase-2（MMP-2） in human rectal tumors and to analyze the clinical significance.Methods Expression of CXCR4 and MMP-2 in 50 cases with rectal tumor were examined by immunohistochemistry method.Then to evaluate the relationship between CXCR4 and MMP-2 expression with clinical and pathological data in human rectal tumors.Results The positive expression of CXCR4 and MMP-2 in rectal cancer tissues were higher than those in normal rectal tissues（P0.01）.The positive expression of CXCR4 and MMP-2 were positively correlated with Dukes stage,tumor＇s differentiation and lymph node metastasis.Conclusion CXCR4 and MMP-2 maybe relate with the infiltration and metastasis of rectalcarcinoma. |
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| Keywords: | colorectal neoplasms CXCR4 matrix metalloproteinase-2 |
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