| 噻氯匹啶对脑血栓病人的血栓烷B_2的抑制 |
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| 引用本文： | 何扬,阮长耿. 噻氯匹啶对脑血栓病人的血栓烷B_2的抑制[J]. 苏州大学学报(自然科学版), 1991, 0(3) |
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| 作者姓名： | 何扬 阮长耿 |
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| 作者单位： | 江苏省血液研究所苏州医学院血栓与止血研究室(何扬)，江苏省血液研究所苏州医学院血栓与止血研究室(阮长耿) |
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| 摘 要： | 应用噻氯匹啶250mg/d 治疗急性脑血栓15例,疗程3个月。结果,血浆中血栓烷B_2浓度于治疗2周后开始持续性降低,对于ADP 诱导的血小板血栓烷B_2生成量,也有显著的抑制作用,提示噻氯匹啶的抗血栓作用与抑制血小板花生四烯酸代谢有关。
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| 关 键 词： | 噻氯匹啶 血栓烷B_2 脑血栓 |
Inhibition of Ticlopidine to Thromboxane B_2 in Cerebral Thrombosis |
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| He Yang,et al. Inhibition of Ticlopidine to Thromboxane B_2 in Cerebral Thrombosis[J]. Suzhou University Journal of Medical Science, 1991, 0(3) |
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| Authors: | He Yang et al |
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| Abstract: | 15 patients with acute cerebral thrombosis were treated withTiclopidine at the dosage of250mg/d for three months.The alterations of TXB_2 level in plasma and platelet TXB_2 productioninduced by ADP were observed.Two weeks after administration of the drug,plasma TXB_2 level de-creased significantly and platelet TXB_2 production induced by ADP was remarkly inhibited.These(?)results suggest that the antiplatelet efficiency of Ticlopidine might be,in part,related to the inhibi-tion of arachidonic acid metabolism in platelets. |
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| Keywords: | Ticlopidine TXB_2 thromosis |
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