NMDAR/PSD-95/nNOs复合体及其解偶联剂在治疗缺血性卒中的应用

缺血性脑卒中是一种高死亡率、高致残率、高复发率的疾病。目前认为，脑卒中是由各种血管性病因引起的急性或局灶性脑功能障碍，且持续时间超过24 h或引起死亡的临床症候群。随着对脑卒中发病机制的深入研究，其治疗药物也日新月异，该文综合国内外文献，根据NMDAR/PSD-95/nNOs复合体结构特点及其如何在缺血性脑卒中产生病理作用，阐明新型解偶联药物在治疗缺血性卒中的应用前景。

NMDAR/PSD-95/nNOs complex and its uncoupler applied in the treatment of ischemic stroke

Ischemic stroke is a disease of high mortality,high morbidity and high recurrence. It is previously believed that stroke is a kind of acute or focal brain dysfunction caused by a variety of vascular etiology,and it lasts longer than 24 hours and may cause death. With further study of the pathogenesis of stroke,medicines for the treatments are also changing. By summarizing on the structure,struc-ture-active relationship and pathological action of complex on the basis of collected literatures at home and abroad,the prospects of new uncoupling drugs in the treatment of ischemic stroke are clarified.