深圳市2003—2005年孕妇梅毒感染状况及影响因素分析

目的了解深圳市孕产妇梅毒感染状况并分析影响因素。方法对所有首次到医院进行孕期保健的孕妇实行免费筛查；采用梅毒甲苯胺红不加热血清试验方法进行初筛，阳性血清送至市性病防治中心，采用梅毒螺旋体颗粒凝集试验等方法进行确认。结果2003-2005年深圳市共筛查418871名孕妇，筛查率为94．7％，确诊梅毒阳性孕妇2019例，平均感染率为0．48％。梅毒阳性孕妇94．2％集中在20-35岁年龄段；孕妇文化程度93．6％为高中以下，初中显著高于其他学历（OR=9．515）；孕妇中63．4％的职业为商业服务和无业，显著高于其他职业（OR=8．628）；孕妇中89．5％为外来人员，高于本地户籍者（OR=8．733）；孕妇首诊孕周越大感染率越高。结论深圳市孕妇人群梅毒感染率仍处于较高水平，与职业、学历、户籍、首诊孕周密切相关。

Study on the status of syphilis inflection and its influence factors on pregnant women in Shenzhen

OBJECTIVE: Through questionnaire and screening, epidemiology of syphilis in pregnant women and related risk factors were studied, to develop effective policy and reducing the negative impact of the disease. METHODS: All pregnant women who appeared at the hospitals the first time, were included, in Shenzhen city. Tolulized Red Unheated Serum Test (TRUST) method was used for primary screening and positive results were confirmed by the Treponema Pallidum Particle Agglutination (TPPA) test at the Shenzhen Center for Disease Control and Prevention (SZCDC). Positive patients were informed and treated and the pregnancies were managed accordingly at the SZCDC. RESULTS: From 2003-2005, 418,871 (94.7%) pregnant were screened. Epidemiological and treatment data were collected from 2019 positive cases of infectious syphilis (0.48%). Among them, 94.2% were between 20 and 35 years old, with 93.6% of them had only junior high school education and 63.4% of them worked as commercial services or jobless which was significantly higher than other occupations (OR = 8.628). 89.5% of them were from other cities, significantly higher than from local residents (OR = 8.733). Gestational weeks at original diagnosis was longer and the infection rate higher. CONCLUSION: The infection rate of syphilis in Shenzhen was still at a high level which was related to occupation, education level, place of residency, gestational weeks at first diagnosis etc. Further screening measures and early intervention were important.