6种抗生素治疗早期梅毒的疗效对比研究

目的：通过对1992～2000年梅毒的临床治疗方法及随访结果回顾性对比分析，以选择最佳有效药物。方法：1516例梅毒按统一环准进行诊断和6种抗生素选择治疗，使用统一的登记表格，由性病专科医生统一填写，汇总、统汁和分析。结果：治疗早期梅毒青霉素治愈率平均达92．30％，头孢曲松钠、米诺环素、多两环素和阿奇霉素治愈率分别为90．13%、87．38％、87．88％和68．54％。青霉素与各组间治愈率对比统计学处理差异有显著性（P〈0．05）。结论：青霉素治疗梅毒仍是首选，且疗效高、价格低，头孢曲松钠、米诺环素、多曲环素则是有效的驱梅替代药物。

Analysis of six kinds of antibiotics in the treatment of early syphilis

Objective: To select the best valid medicine which can cure the early syphilis fast and thoroughly,provide comprehensive clinical information after the comparative analysis of clinical therapy and results of follow-up in syphilis cases from 1992 to 2000.Methods: 1 516 syphilis cases were diagnosed and treated with different kind of six antibiotics based on the same standard.The specialists of venereal diseases statistically calculated and analyzed the results on the filled registers.Results: Penicillin cure rate was 92.30%.The cure rates of ceftriaxone sodium,minocycline,doxycycline and azithromycin were 90.13%,87.38%,87.88% and 68.54% respectively.The difference in the cure rate between penicillin and other 5 antibiotics applied had statistical significance(P<0.05).(Conclusion): Penicillin is still the first choice to treat syphilis with curative effect and low price.Ceftriaxone sodium,minocycline,doxycycline are valid alternative medicines for syphilis.