18F-FDG标准摄取值对非小细胞肺癌预后的影响

目的:探讨18F-FDG标准摄取值(SUV)在判断非小细胞肺癌预后中的作用。方法:对122例非小细胞肺癌(NSCLC)经PET显像并计算出肺部肿瘤病灶感兴趣区(ROI)的SUV。结果:单变量分析结果显示,临床分期、身体状况及病理学类型间生存曲线有显著性差异(P<0.01);SUV>7的患者与SVU≤7患者间生存曲线差异有显著性(P<0.05),性别对生存期影响无显著性差异(P>0.05);COX多因素分析显示,总生存率与临床分期、身体状况、病理学类型及SUV大小(SUV>7和SVU≤7)密切相关,而性别对总的生存率无影响。结论:SUV值能够预测NSCLC的生物学恶性进程,并为临床治疗方案的选择和预后判断提供参考。

The Effect of Standardized Uptake Value of 18F-FDG-PET on Prognosis of Non-small Cell Lung Cancer

Objective: The study investigated the relationship between the standardized uptake value (SUV) and prognosis in patients with non-small cell lung cancer (NSCLC). Methods: 122 patients confirmed NSCLC underwent 18F-FDG-positron emission tomography (PET) imaging. SUV was calculated in regions of interest(RIO) of pulmonary lesions on PET scans. Results: In the univariate analysis, performance status (P<0.01), stage (P<0.01), Tumor-cell type (P<0.01). SUV greater than 7 (P<0.05), were correlated with bad survival. However, there was no significant difference in gender (P>0.05). Multivariate Cox model analysis indicated that the overall survival was significantly related to performance status (P<0.01), stage(P<0.01), Tumor-cell type(P<0.01) and SUV (P<0.05). Conclusion: The results suggested that the 18F-FDG uptake in primary NSCLC with PET may play an important prognostic value and could be complementary to other well-identified factors in the decision on adjuvant treatment protocols.