| 紫外分光光度法测定盐酸奈福泮-β-环糊精包合物的含量 |
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| 引用本文： | 关皓月,张纯,顾伟锋.紫外分光光度法测定盐酸奈福泮-β-环糊精包合物的含量[J].药学实践杂志,2008,26(4):291-293. |
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| 作者姓名： | 关皓月 张纯 顾伟锋 |
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| 作者单位： | 第二军医大学长征医院药学部,上海,200003 |
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| 摘 要： | 目的:建立测定盐酸奈福泮-β-环糊精包合物中盐酸奈福泮含量的方法.方法:采用紫外分光光度法测定含量,测定波长为267 nm.用乙酸乙酯洗脱未包封的盐酸奈福泮,测定被包封的盐酸奈福泮含量及包封率.结果:盐酸奈福泮检测浓度在0.01～0.4 mg/mL范围内线性关系良好(r=0.999 5,n=9);日内RSD=0.17%(n=5),日间RSD=1.82%(n=5);平均加样回收率为100.39%(n=9);测得3批样品的包封率分别为73.28%、70.37%、74.97%.结论:该方法操作简便、结果准确,适用于盐酸奈福泮-β-环糊精包合物中盐酸奈福泮含量的测定.
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| 关 键 词： | 紫外分光光度法 盐酸奈福-β-环糊精包合物 盐酸奈福泮 含量测定 |
| 收稿时间： | 2007/6/11 0:00:00 |
Determination of nefopam hydrochloride(NFH)in nefopam NFH-β-cyclodextrin inclusion compound by UV spectrophotometry |
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| GUAN Hao-yue,ZHANGChun and GU Wei-feng.Determination of nefopam hydrochloride(NFH)in nefopam NFH-β-cyclodextrin inclusion compound by UV spectrophotometry[J].The Journal of Pharmaceutical Practice,2008,26(4):291-293. |
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| Authors: | GUAN Hao-yue ZHANGChun and GU Wei-feng |
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| Institution: | Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China;Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China;Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China |
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