| 丹参酮对实验性心肌肥厚大鼠凋亡相关因子表达的影响 |
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| 引用本文： | 杨春光,孙长滨,曲鹏,杨权,李佳.丹参酮对实验性心肌肥厚大鼠凋亡相关因子表达的影响[J].中国实用医药,2008,3(28):3-4. |
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| 作者姓名： | 杨春光 孙长滨 曲鹏 杨权 李佳 |
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| 作者单位： | 大连大学医学院,116622 |
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| 基金项目： | 大连大学创新教育基金项目资助
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| 摘 要： | 目的探讨丹参酮对异丙肾上腺素诱导的心肌细胞肥大的影响。方法采用皮下注射异丙肾上腺素造成心肌肥厚大鼠模型,通过免疫组织化学方法观察丹参酮对肥大心肌细胞凋亡相关因子Fas、Bcl-2表达的影响。结果异丙肾上腺素组大鼠心肌肥厚,Fas、Bcl-2基因表达增加（P〈0.05）,加入丹参酮干预后,Fas基因表达减弱（P〈0.05）,Bcl-2基因表达增加（P〈0.05）。结论丹参酮具有保护心肌,预防心肌肥厚的作用,其机制可能与抑制Fas基因表达,增加Bcl-2基因表达有关。
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| 关 键 词： | 丹参酮 心肌肥厚 细胞凋亡相关基因 |
Effects of tanshinone on apoptosis related gene expression in experimental cardiac hypertrophy in rats |
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| YANG Chun-guang,SUN Chang-bin,QU Peng,et al..Effects of tanshinone on apoptosis related gene expression in experimental cardiac hypertrophy in rats[J].China Practical Medical,2008,3(28):3-4. |
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| Authors: | YANG Chun-guang SUN Chang-bin QU Peng |
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| Institution: | YANG Chun-guang,SUN Chang-bin,QU Peng,et al.Medical College of Dalian University,Dalian 116622,China |
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| Abstract: | Objective To study the effects and mechanisms of tanshinone on isoproterenol induced cardiac hypertrophy in rats.Methods Cardiac hypertrophy rat model was induced by subcutaneous injection of isoprenaline.The myocardial expression of apoptosis related genes,Fas and Bcl-2 were detected by immuno-histochemical technique in cardiac hypertrophy rats treated by tanshinone.Results The expression of apoptosis related genes,Fas and Bcl-2 were increased in cardiac hypertrophy rats induced by isoprenaline(P<0.05),but the expression of Fas was decreased(P<0.05)and Bcl-2 was increased in rats treated by tanshinone(P<0.05).Conclusion Tanshinone may protect myocardium against hypertrophy.The suppression of myocardial hypertrophy might be associated with the decrease of Fas and increased of Bcl-2 expression caused by tanshinone. |
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| Keywords: | Tanshinone Cardiac hypertrophy Apoptosis related gene |
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