| 系统生物学在中药复方研究中的应用 |
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| 引用本文： | 窦圣姗,柳润辉,姜鹏,张川,张卫东,刘磊,罗国安. 系统生物学在中药复方研究中的应用[J]. 世界科学技术, 2008, 10(2): 116-121 |
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| 作者姓名： | 窦圣姗 柳润辉 姜鹏 张川 张卫东 刘磊 罗国安 |
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| 作者单位： | [1]第二军医大学药学院,上海200433 [2]湖南中医药大学,长沙410007 [3]清华大学化学系生命有机磷与化学生物学教育部重点实验室／清华大学生命科学与医学研究院中药现代化研究中心,北京100084 |
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| 基金项目： | 科技部支撑计划项目，教育部跨世纪优秀人才培养计划，上海市科委资助项目 |
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| 摘 要： | 中药复方的现代化一直是中医药界多年来关注的焦点。由于中药复方多成分、多靶点的作用特点，其作用物质及机理研究一直处于“知其然，不知其所以然”的尴尬地位，无法进行科学、全面、准确的阐述。系统生物学的提出，为中药复方的研究提供了崭新的思路和方法，成为当今中药研究中的热点领域。系统生物学从整体观出发，系统研究中药复方的药效物质基础、配伍规律、广泛的药理及其作用机理，为打破长久以来困扰中医药研究的“黑匣”问题提供了契机。本文对系统生物学的思路、方法及其在中药复方研究中的应用与发展进行了综述和评价。
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| 关 键 词： | 系统生物学 中药复方 应用 |
System Biology and Its Application in TCM Formula Study |
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| Dou Shengshan,Liu Runhui,Jiang Peng,Zhang Chuan,Zhang Weidong,Liu Lei,Luo Guoan. System Biology and Its Application in TCM Formula Study[J]. World Science and Technology(Modernization of Traditional Chinese Medicine), 2008, 10(2): 116-121 |
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| Authors: | Dou Shengshan Liu Runhui Jiang Peng Zhang Chuan Zhang Weidong Liu Lei Luo Guoan |
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| Affiliation: | Dou Shengshan,Liu Runhuil, Jiang Peng, Zhang Chuan, Zhang Weidong,Liu Lei,Luo Guoan(1.School of Pharmacy, Second Military Medical University; Shanghai 200433;2.Hunan University of Traditional Chinese Medicine, Changsha 41007 ;3. Key Lab of Chemical Biology under Ministry of Education Department of Chemistry, Tsinghua University;Modem Research Center of TCM,Institute of Biomedicine, Tsinghua University,Beijing 100084) |
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| Abstract: | The development of traditional Chinese medicine （TCM） formula in a modernized context has been an endeavor of the TCM industry for many years, though TCM has not yet been understood in a clear manner of its physical basis and mechanism, due to its multi-component and multi-targets nature. Fortunately, system biology is in a position to provide novel insights for TCM study. This means, some difficult spots of TCM formula study, including the physical basis of TCM therapeutic effects, compatibility, pharmacology and action mechanism, will be addressed in an effective manner, and the problem of ＂black box＂ in TCM study fully understood, with the help of system biology. In this review, authors discussed different thoughts and methods of system biology and their applications in TCM formula study. |
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| Keywords: | system biology traditional Chinese medicine formula |
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