46例民航飞行员血清尿酸水平与冠心病的相关分析

目的 研究血清尿酸（serum uric acid,SUA）水平与民航飞行员冠状动脉粥样硬化性心脏病（冠心病）的相关性.方法 对46例疑似冠心病的民航飞行员行冠状动脉造影,并采集空腹静脉血样测定血清尿酸、血糖及血脂水平,分析上述生化指标、病史、年龄与冠心病的相关性.结果 经冠状动脉造影,18例（39.1%）确诊冠心病,列为冠心病组;28例（60.9%）冠状动脉造影正常或病变轻微,列为非冠心病组.两组间年龄差异有统计学意义（t=2.187,P＜0.05）;合并高血压、低高密度脂蛋白胆固醇血症及高尿酸血症方面差异有统计学意义（P＜0.05）;但在合并糖尿病、吸烟、高胆固醇血症、高甘油三酯血症、高低密度脂蛋白胆固醇血症方面差异无统计学意义（P＞0.05）;冠心病组飞行员平均血清尿酸水平为（430.58±89.10） μmol/L,明显高于非冠心病组的（341.70±78.11） μmol/L,差异有统计学意义（t=3.565,P＜0.01）.精确Logistic检验结果显示SUA是冠心病的独立危险因素.结论 高尿酸血症可能是引起飞行员冠心病的独立危险因素.

Analysis of serum uric acid level correlated to coronary heart disease in 46 civil pilots

Objective To investigate the correlation between the serum uric acid (SUA) level and the coronary heart disease (CHD) events in Chinese civil pilots. Methods Fasting blood samples were collected from 46 civil pilots who were likely diagnosed as CHD, and coronary arteriongraphy was conducted for final diagnosis in these subjects. The SUA levels, fasting blood glucose and blood lipid profile were measured and the correlation between CHD events and the above-mentioned biochemical results, history and age were statistically analyzed. Results Eighteen patients (39.1%) were diagnosed as CHD, while 28(60.9%) had no or minor abnormalities determined by coronary arteriongraphy, so as to be classified into CHD or non-CHD group respectively. The differences on age and the association of hypertension, low high density lipoprotein concentrations and hyperuricemia were significant between two groups (P<0.05), but on the association of diabetes, smoking, high cholesterol, high triglyceride and high low density lipoprotein concentrations (P>0.05). The mean SUA level in CHD group was significantly higher than that in non-CHD group (430.58±89.10) μmol/L vs (341.70±78.11) μmol/L] (t=3.565, P<0.01). Furthermore, the exact Logistic regression indicated that the SUA concentration was the independent risk factor against CHD incidence. Conclusion The elevation of SUA might be an independent risk factor that induced CHD in pilot.