乳酸-羟基乙酸共聚物纳米粒的研究进展★

摘要: 乳酸-羟基乙酸共聚物是目前被认为最具发展前景的生物医用高分子可降解材料之一，对近年来乳酸-羟基乙酸共聚物纳米粒的制备方法和改性研究进行分析。目前制备乳酸-羟基乙酸共聚物纳米粒药物载体的方法主要有沉淀法、乳化溶剂挥发法、溶剂扩散法、喷雾干燥法等。乳酸-羟基乙酸共聚物纳米粒的表面涂层、表面接枝、表面特异性配体修饰及与其他高聚物共聚、与无机物复合是改性研究的热点。乳酸-羟基乙酸共聚物纳米粒药物载体的制备技术和改性研究方法较多，但尚未完全解决临床应用上如何控制药物适量的突释，使血药浓度快速达到有效治疗浓度而不导致杀死正常细胞等一些问题，乳酸-羟基乙酸共聚物纳米粒系统有待进一步的完善。

Research progress in poly (lactic-co-glycolic acid) nanoparticles

Abstract: Poly (lactic-co-glycolic acid) (PLGA) was currently considered to be the most promising biomedical degradable polymer materials. This study aimed to analyze preparation techniques and modified research progress of PLGA nanoparticles. Present methods in preparation of PLGA nanoparticles include nano-precipitation, emulsion solvent evaporation methods, spray-drying methods and so on. Surface coating, surface grafting, surface specific ligand modification and copolymerization with other polymers and inorganic compound are the hot spots of PLGA nanoparticles modified research. There were many preparation methods of the nanoparticles drug carrier technology and modification, but not yet completely resolved some problems, such as drug control to reach an effective therapeutic concentration to avoid killing normal cells in clinic. PLGA nanoparticles system deserves further improvement.