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Trisomy/ tetrasomy of chromosome 8 and +i(8q) as the sole chromosome abnormality in three adult patients with myelomonocytic leukemia |
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| Authors: | Ferro M T Vázquez-Mazariego Y Ramiro S Santiago M F García-Sagredo J M Nuñez R Hernández J M San Roman C |
| Affiliation: | a Department of Medical Genetics, University Hospital Ramón y Cajal, Madrid, Spain b Department of Haematology, University Hospital Ramón y Cajal, Madrid, Spain c Department of Haematology, University of Medicine, Salamanca, Spain. |
| Abstract: | We report three cases of tetrasomy 8 associated with myeloid disease. Two patients had chronic myelomonocytic leukemia (CMMoL) and the other had acute monocytic leukemia (AML M5 FAB). Two patients had trisomy/tetrasomy chromosome 8 as the sole abnormality. The other patient with CMMoL had two normal 8 chromosomes plus one isochromosome 8q; this is the first case of long arm chromosome 8 tetrasomy without short arm 8 monosomy. This cytogenetic finding suggests the importance of the genes located in the long arms of chromosome 8. |
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