小剂量普萘洛尔治疗婴幼儿血管瘤的临床观察

目的：探讨小剂量普萘洛尔治疗婴幼儿血管瘤的疗效及安全性。方法：收集增生期婴幼儿血管瘤23例（男6例,女17例）,口服普萘洛尔0.5～0.75 mg/（kg.d）,疗程1～9个月,并进行疗效评定和安全性评价。结果：疗效评定：优6例（26.1%）,良9例（39.1%）,中等8例（34.8%）;不良反应包括：心率轻度减慢8例（34.78%）,睡眠障碍2例（8.7%）,腹泻1例（4.3%）。不良反应轻,均1周内自行消失;安全性评定：15例为安全,8例为比较安全。结论：小剂量普萘洛尔治疗婴幼儿血管瘤,疗效良好,不良反应轻,安全性较好。

Clinical observations on infantile hemangiomas treated with low-dose propranolol

Objective To explore the efficacy and safety of low-dose propranolol in the treatment of infantile hemangiomas.Methods A total of 23 infants（6 males and 17 females） with proliferative hemangiomas were treated with propranolol.Propranolol was orally administered at 0.5 to 0.75 mg/kg/day.The total time of therapy was 1 month to 9 months.The efficacy and safety of medication was evaluated after finishing treatment.Results Response to propranolol therapy was excellent in 6 patients（26.1%）,good in 9 patients（39.1%）,fair in 8 patients（34.8%） and none poor.Mild adverse effects were noted in 8 patients（34.8%）,including heart rate gently slowing（34.8%）,mild sleep disorder（8.7%） and diarrhea（4.3%）.The adverse effects disappeared within one week of their occurrence,needing no special handling.Safety evaluation of therapy showed safe in 15 patients（65.2%）,relative safe in 8 patients（34.8%）.Conclusions Low-dose propranolol is effective and safe in the treatment for infantile hemangiomas,with only limited and mild side effects.