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| 改良永久性线栓法制作大鼠大脑中动脉梗阻模型的探讨 | |
| 引用本文： | 潘江,章薇,葛卫军,陈武善,石文英,潘纯,罗容. 改良永久性线栓法制作大鼠大脑中动脉梗阻模型的探讨[J]. 湖南中医药大学学报, 2011, 31(3): 24-26,44 |
| 作者姓名： | 潘江 章薇 葛卫军 陈武善 石文英 潘纯 罗容 |
| 作者单位： | 1. 湖南中医药大学2008级硕士研究生班,湖南,长沙,410208: 2. 湖南中医药大学第一附属医院,湖南,长沙,410007 |
| 基金项目： | 湖南省高校科技创新平台基金项目 |
| 摘 要： | 目的 研究改良线栓法制作大脑中动脉梗阻(MCAO)大鼠模型。方法将20只SD大鼠分为Zea Longa组(A组)、改良线栓法组(B组),并对其造模手术时间、梗死体积、神经功能缺损评分进行比较。结果改良永久性线栓法制作大鼠MCAO模型所用时间与Zea Longa线栓法所需时间比较差异具有统计学意义(P<0.05),梗死体积、神经功能缺损评分两者比较,差异无统计学意义(P>0.05)。结论改良永久性线栓法能减少造模时间,提示其梗死体积、神经功能缺损评分,差异无统计学意义(P>0.05),均提示其造模成功。 |
| 关 键 词： | 大鼠MCAO模型 改良线栓法 脑缺血模型 |
Study on modified permanent suture for preparation of middle cerebral artery obstruction model in rats |
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| PAN Jiang,ZHANG Wei,GE Wei-jun,CHEN Wu-shan,SHI Wen-ying,PAN Chun,LUO Rong. Study on modified permanent suture for preparation of middle cerebral artery obstruction model in rats[J]. Journal of Traditional Chinese Medicine University of Hunan, 2011, 31(3): 24-26,44 | |
| Authors: | PAN Jiang ZHANG Wei GE Wei-jun CHEN Wu-shan SHI Wen-ying PAN Chun LUO Rong |
| Affiliation: | (TCM University of Hunan,Changsha,Hunan 410208,China) |
| Abstract: | Objective To study a modified suture for preparation of middle cerebral artery obstruction(MCAO) model in rats.Method 20 SD rats were divide into Zea Longa group(group A) and modified suture group(group B) and compare the operating time,infarction volume and neurologic deficits rate.Results The time using modified permanent suture to prepare the MCAO model was shorter than that in group A(P<0.05),the differences of infarction volume and neurologic deficits score between the two groups were statistically significant(P>0.05).Conclusion The modified permanent suture can reduce the modeling time and not affect model made. |
| Keywords: | MCAO rats model modified suture method cerebral ischemia model |
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