2型糖尿病患者颈动脉内膜中层厚度危险因素的病例对照研究

目的 探讨2型糖尿病颈动脉内膜增厚的影响因素.方法 采用病例对照研究,研究对象来自广州市第一人民医院住院部,其中病例组(颈动脉内膜中层厚度＞1.0 mm)51例,对照组(颈动脉内膜中层厚度≤1.0 mm)51例,采用Logistic回归模型筛选2型糖尿病患者颈动脉内膜增厚的危险因素.结果 病例组与对照组在糖化血红蛋白(HbA1c)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)以及水果摄入量方面差异具有统计学意义(P＜0.05).Logistic回归分析显示,糖化血红蛋白(HbA1c)是2型糖尿病患者颈动脉内膜中层厚度的危险因素(OR=1.233),水果摄入量是2型糖尿病患者颈动脉内膜中层厚度的保护因素(OR=0.993).结论 HbA1c是2型糖尿病血管并发症的良好预测指标.倡导健康生活方式、合理的膳食结构,是预防与延缓2型糖尿病患者血管病变的重要措施.

A case-control study on risk factors of carotid intima-media thickness (C-IMT) in patients with type 2 diabetes

Objective To assess the risk factors of carotid intima-media thickness（C-IMT） in type 2 diabetes mellitus（T2DM）.Methods A case-control study was performed in 102 cases with type 2 diabetes mellitus,including 51 cases（C-IMT〉1.0 mm） and 51 matched controls（C-IMT≤1.0 mm） recruited from Guangzhou first municipal people＇s hospital.The conditional Logistic regression was used to screen out the risk factors of the carotid intima-media thickness.Results HbA1c,total cholesterol（TC）,low-density lipoprotein cholesterol（LDL-C） and fruits intakes were significantly different between the case group and control group.After adjustment for potential risk factors,it showed that HbA1c（OR= 1.233） was the risk factor of the carotid intima-media thickness in type 2 diabetes mellitus（T2DM） patients,while fruits intake（OR=0.993） was a protective factor of C-IMT in T2DM patients.Conclusions HbA1c was a strong predictor of vascular complications in type 2 diabetes mellitus.Healthy life style and reasonable dietary structure may be an effective program to prevent type 2 diabetes mellitus patients from vascular complications.