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| MTHFR C677T基因多态性与高同型半胱氨酸型高血压关联性研究 | |
| 引用本文： | 梁长流,蒋善群,彭少杰,陈常中,张岩,李建平,霍勇,徐希平. MTHFR C677T基因多态性与高同型半胱氨酸型高血压关联性研究[J]. 疾病控制杂志, 2011, 15(6): 480-484 |
| 作者姓名： | 梁长流 蒋善群 彭少杰 陈常中 张岩 李建平 霍勇 徐希平 |
| 作者单位： | 1. 安徽医科大学生物医学研究所,安徽,合肥,230032 2. 安徽大学生命科学学院,安徽,合肥,230000 3. 哈佛大学Brigham and Women医院,美国,波士顿,02115 4. 北京大学第一附属医院心内科,北京,100034 |
| 摘 要： | 目的 探索安徽农村地区影响高同型半胱氨酸型高血压(H型高血压)发生的基因和环境危险因素.方法 在安徽农村地区入选226名高血压患者,测定N5,10-亚甲基四氢叶酸还原酶(MTHFR)C677T基因型和血浆同型半胱氨酸(Hcy)水平.结果 (1)所调查的高血压人群男性Hcy水平显著高于女性(P<0.01);男性H型高血压患病率(71.3%)高于女性(48.0%).(2)TT基因型与CC+CT基因型相比,Hcy水平显著增加,H型高血压的比例显著增加.(3)其他相关变量与Hcy水平的多元线性回归模型及与H型高血压多因素Logistic回归模型分析,均未发现年龄、吸烟、饮酒和体质指数与Hcy水平有显著性的相关(均有P>0.05).结论 安徽农村地区高血压人群中MTHFR C677T基因突变可能是H型高血压发病的重要遗传因素且存在性别差异,建议该人群应该尽早做相关的检测以检查是否发生高同型半胱氨酸血症. |
| 关 键 词： | 高血压 多态性,单核苷酸 半胱氨酸 |
Association study of MTHFR C677T genotype with H-type hypertension |
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| LIANG Chang-liu,JIANG Shan-qun,PENG Shao-jie,CHEN Chang-zhong,ZHANG Yan,LI Jian-ping,HUO Yong,Xu Xi-ping. Association study of MTHFR C677T genotype with H-type hypertension[J]. Chinese Journal of Disease Control and Prevention, 2011, 15(6): 480-484 | |
| Authors: | LIANG Chang-liu JIANG Shan-qun PENG Shao-jie CHEN Chang-zhong ZHANG Yan LI Jian-ping HUO Yong Xu Xi-ping |
| Affiliation: | LIANG Chang-liu1,JIANG Shan-qun2,PENG Shao-jie1,CHEN Chang-zhong3,ZHANG Yan4,LI Jian-ping4,HUO Yong4,Xu Xi-ping1.1.Biomedical Institute,Anhui Medical University,Hefei 230032,China,2.School of Life Sciences,Anhui University,Hefei 230000,3.Brigham and Women Hospital,Harvard University,Boston 02115,USA,4.Department of Cardiology,the First Affiliated Hospital of Peking University,Beijing 100034 |
| Abstract: | Objective To explore the impacts of genetic and environmental factors on H-type hypertension risk in Anhui rural area.Methods A total of 226 patients of hypertension from Anhui were selected.C677T polymorphism in MTHFR gene and plasma homocysteine(Hcy) level were detected.Results(1)The average level of Hcy in men was significantly higher than that in women(P<0.01);percentage of H-type hypertension in male patients(71.3%) was significantly higher than that in female patients(48.0%).(2)The subjects with TT ge... |
| Keywords: | Hypertension Polymorphism single nucleotide Cysteine |
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