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Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer |
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| Authors: | Jürgen Veeck Peter J Wild Thomas Fuchs Peter J Schüffler Arndt Hartmann Ruth Knüchel Edgar Dahl |
| Affiliation: | (1) Molecular Oncology Group, Institute of Pathology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, D-52074 Aachen, Germany;(2) Institute of Surgical Pathology, University Hospital Z?rich, Schmelzbergstrasse 12, CH-8091 Z?rich, Switzerland;(3) Institute for Computational Science and Department of Computer Science, ETH Z?rich, Universit?tsstrasse 6, CH-8092 Z?rich, Switzerland;(4) Department of Pathology, University of Erlangen, Krankenhausstrasse 12, D-91054 Erlangen, Germany;(5) Cancer Epigenetics and Biology Program (PEBC), Bellvitge Institute for Biomedical Research (ICO-IDIBELL), Hospital Duran i Reynals, Av. Gran Via de L'Hospitalet 199-203, E-08907 Barcelona, Spain |
| Abstract: | BackgroundSecreted Wnt signaling antagonists have recently been described as frequent targets of epigenetic inactivation in human tumor entities. Since gene silencing of certain Wnt antagonists was found to be correlated with adverse patient survival in cancer, we aimed at investigating a potential prognostic impact of the two Wnt antagonizing molecules WIF1 and DKK3 in breast cancer, which are frequently silenced by promoter methylation in this disease. |
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