| 散发性帕金森病患者γ-synuclein基因的研究 |
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| 引用本文： | 苏敬敬,谢惠君,赵武伟,韩海雄,高彤,徐玲,汤国梅,任大明. 散发性帕金森病患者γ-synuclein基因的研究[J]. 中华医学遗传学杂志, 2003, 20(5): 444-446 |
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| 作者姓名： | 苏敬敬 谢惠君 赵武伟 韩海雄 高彤 徐玲 汤国梅 任大明 |
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| 作者单位： | 1. 200433,上海,第二军医大学附属长海医院神经内科
2. 复旦大学遗传所 |
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| 摘 要： | 目的 探讨γ-synuclein基因C243G和A377T多态在散发性帕金森病(Parkinson’s disease，PD)的疾病易感性中的意义。方法 采用聚合酶链反应-限制性片段长度多态法，对上海汉族人中145例PD患者和184名正常人进行γ-synuclein基因C243G和A377T多态分型，并作与PD的遗传关联研究。结果 PD患者与正常对照间γ-synuclein基因C243G和A377T多态分布的差异无显著性，两种多态与PD亦无关联(P值均大于0．05)。结论 上海地区汉族人群中γ-synuclein基因C243G和A377T多态与散发性PD无关。
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| 关 键 词： | 散发性帕金森病 γ-synuclein基因 PD 染色体 遗传性疾病 |
| 修稿时间： | 2002-10-21 |
Study on γ-synuclein gene in patients with idiopathic Parkinson''s disease |
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| SU Jing-jing ,XIE Hui-jun ,ZHAO Wu-wei ,HAN Hai-xiong ,G AO Tong ,XU Ling ,TANG Guo-mei ,REN Da- ming .. Study on γ-synuclein gene in patients with idiopathic Parkinson''s disease[J]. Chinese journal of medical genetics, 2003, 20(5): 444-446 |
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| Authors: | SU Jing-jing XIE Hui-jun ZHAO Wu-wei HAN Hai-xiong G AO Tong XU Ling TANG Guo-mei REN Da- ming . |
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| Affiliation: | Department of Neurology, Changhai Hospital, the Second Military Medical University, Shanghai, 200433 P R China. jjsulcg@yahoo.com |
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| Abstract: | OBJECTIVE: To evaluate the relationship between idiopathic Parkinson's disease (PD) and two polymorphisms (C243G and A377T) of the gamma-synuclein gene in a Chinese Han population of Shanghai area. METHODS: Polymorphic genotyping was performed with PCR-RPLP technique. Association analysis was carried out in 145 unrelated idiopathic PD patients and 184 age-matched healthy controls. RESULTS: The authors failed to detect any distributional difference of the C243G and A377T polymorphisms of the gamma-synuclein gene between PD cases and control subjects, nor did they find any association. CONCLUSION: These data do not support that gamma-synuclein gene C243G and A377T polymorphisms are involved in idiopathic PD onset in the Han population of Shanghai area. |
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