低浓度二硫化碳慢性染毒对大鼠肝和血浆铜,锌水平的影响

了解长期接触低浓度二硫化碳（ＣＳ２）对机体铜、锌水平的影响。方法ＳＤ大鼠４８只随机分为三组，两个接触组分别吸入浓度为５ｍｇ／ｍ３和５０ｍｇ／ｍ３的ＣＳ２，每日５小时，每周６日，连续６个月。对照组吸自然空气。三组各在染毒前及染毒２、４和６个月时测血及肝铜、锌水平。结果５０ｍｇ／ｍ３ＣＳ２接触组在染毒６个月时血浆和肝脏铜水平显著降低（Ｐ＜０．０５），而５ｍｇ／ｍ３ＣＳ２接触组血浆及肝脏铜、锌水平均无显著性改变。结论长期接触ＣＳ２能干扰机体铜代谢，引起体内铜水平的降低；现行的生产车间空气中ＣＳ２最高容许浓度（１０ｍｇ／ｍ３）不会引起机体铜、锌代谢障碍。

Effects of chronic exposure to low concentration carbon disulfide on the lvevls of copper and zinc in rats

Objective To explore the effects of chronic exposure to low concentration carbon disulfide on the copper ard zinc level. Methods Sprague-Dawley rats inhaled CS2 vapour 5 hours a day, 6 days a week for six months. The CS2 concentrations were 5 mg/M3 and 50mg/M3 respectively. Results : The levels of copper in plasma and liver both were significntly decreased .(P <0. 05 ) in the group that inhaled 50 mg/M3 CS2 vapour after six months exposure. but there was no significant difference in the levels of copper or zinc in plasma or liv- er in the group that inhaled 5mg/M3 CS 2 vapour and the control. Conclusion : Exposure to CS2 can interfere with copper metabolism and decrease copper level in organisms. The current CS2 maximum allowable concentration (MAC ) is still regarded as safe.