D-二聚体/hs-CRP比值在社区获得性肺炎合并肺栓塞中的诊断价值初探

目的:初探D-二聚体/超敏C反应蛋白(hs-CRP)比值在社区获得性肺炎(CAP)合并肺栓塞中的诊断价值。方法:本研究为病例对照研究。采用非随机抽样方法收集并分析2018年8月至2021年7月深圳市第二人民医院就诊的CAP患者115例，根据肺血管造影结果分为CAP合并肺栓塞组( n＝48)和单纯CAP组( ...

Diagnostic value of D-dimer/hs-CRP ratio on community-acquired pneumonia combined with pulmonary embolism

Objective To explore the diagnostic value of D-dimer/high-sensitivity C-reactive protein(hs-CRP)ratio in community-acquired pneumonia(CAP)combined with pulmonary embolism.Methods In this non-randomized case-control study collecting and analyzing the data of 115 CAP patients treated in Shenzhen Second People′s Hospital from August 2018 to July 2021.According to the results of pulmonary angiography(CTPA),they were divided into CAP combined with pulmonary embolism group(n=48)and CAP alone group(n=67),the aiming was to compare between groups serum white blood cell count(WBC),hs-CRP,D-dimer,erythrocyte sedimentation rate(ESR),FDP,and D-dimer/hs-CRP ratio,and analyze the ROC curve of each index for the diagnosis of pulmonary embolism.Results There was no significant difference in gender,age,WBC,FDP,and ESR between groups(all P>0.05);in CAP patients combined with pulmonary embolismthe the median level of D-dimer,the ratio of D-dimer/hs-CRP was significantly higher than those of patients in CAP alone group,D-dimer(3.843.43,4.72])mg/L vs(1.551.33,1.81])mg/L and D-dimer/hs-CRP(0.210.81,0.25])vs(0.050.05,0.06])respectively;and the value of hs-CRP was lower than that of the CAP alone group(18.9516.21,29.39])mg/L vs(32.6626.43,43.40]mg/L),with statistically significant difference(all P<0.05).Logistic regression indicated that D-dimer,hs-CRP,venous thrombus were risk factors for CAP combined with pulmonary embolism(all P<0.05);ROC curve results suggest the area under the curve of hs-CRP,D-dimer,D-dimer/hs-CRP ratio diagnosing of CAP combined with pulmonary embolism(AUC)were 0.618,0.781,0.858,all P<0.05,respectively.Conclusions In diagnosis of CAP combined with pulmonary embolism hs-CRP,D-dimer and D-dimer/hs-CRP ratios have certain significance.D-dimer/hs-CRP ratio has a higher diagnostic value for those patients in comparison with other serological indicators,especially in significantly increased D-dimer/hs-CRP ratio are pivotal to rapidly address the clinical identification for CAP combined with pulmonary embolism.